INCB-9471

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H40F3N5O2
Molecular Weight	559.6661
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCO[C@@H]1CC2=C(C=CC(=C2)C(F)(F)F)[C@H]1N3CCN(C[C@@H]3C)C4(C)CCN(CC4)C(=O)C5=C(C)N=CN=C5C

InChI

InChIKey=ZMCJFJZOSKEMOM-DNKZPPIMSA-N

InChI=1S/C30H40F3N5O2/c1-6-40-25-16-22-15-23(30(31,32)33)7-8-24(22)27(25)38-14-13-37(17-19(38)2)29(5)9-11-36(12-10-29)28(39)26-20(3)34-18-35-21(26)4/h7-8,15,18-19,25,27H,6,9-14,16-17H2,1-5H3/t19-,25+,27+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C30H40F3N5O2
Molecular Weight	559.6661
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24900235 | https://clinicaltrials.gov/ct2/show/NCT00393120 | https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20080313&CC=WO&NR=2008030853A2&KC=A2

INCB9471 is a non-competitive, potent and selective CCR5 small-molecule antagonist patented by pharmaceutical company Incyte Corporation for treatment of human immunodeficiency virus infection. INCB9471 potently inhibited macrophage inflammatory protein-1beta-induced monocyte migration and infection of peripheral blood mononuclear cells by a panel of R5-HIV-1 strains. INCB9471 was shown to be safe and highly efficacious in reducing HIV viral load in phase I and II human clinical trials

Originator

Approval Year

PubMed

Title	Date	PubMed
Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity.	2010 Dec 9	24900235

Patents

Sample Use Guides

In Vivo Use Guide

300 mg orally once daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:58:51 GMT 2023` Edited by `admin` on `Sat Dec 16 04:58:51 GMT 2023`
Record UNII	C5D4W25708
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INCB-9471

Common Name

English

INCB-009471

Code

English

INCB9471

Code

English

PIPERIDINE, 1-((4,6-DIMETHYL-5-PYRIMIDINYL)CARBONYL)-4-((3S)-4-((1R,2R)-2-ETHOXY-2,3-DIHYDRO-5-(TRIFLUOROMETHYL)-1H-INDEN-1-YL)-3-METHYL-1-PIPERAZINYL)-4-METHYL-

Systematic Name

English

INCB009471

Code

English

Code System Code Type Description

DRUG BANK

DB12960