PICOBENZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H16N2O
Molecular Weight	240.3003
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(=CC(C)=C1)C(=O)NCC2=CC=NC=C2

InChI

InChIKey=JROSDBYIFZWPBP-UHFFFAOYSA-N

InChI=1S/C15H16N2O/c1-11-7-12(2)9-14(8-11)15(18)17-10-13-3-5-16-6-4-13/h3-9H,10H2,1-2H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H16N2O
Molecular Weight	240.3003
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3720794 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 978, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/2861167

Picobenzide is a synthetic product which is of therapeutic interest owing to its neuroleptic, anti-inflammatory and spasmolytic action and because its properties are similar to those of the phenotiazines. The product is largely metabolized into the N-oxide form and is also partially eliminated in urine in an unaltered state.

Approval Year

PubMed

Title	Date	PubMed
[Comparative study of the pharmacological activity of N-(4-picolyl)-3,5-dimethylbenzamide (M-14012-4) and its N-oxide metabolite (M-3312-4). New pharmacological aspects].	1979 Dec	44673
[Pharmacokinetic study of the picobenzide endovenously administered (author's transl)].	1980 Aug	7469499
[Modification of the triphasic mortality curve of d-amphetamine].	1982 Dec	7183249
Determination of N-oxide of picobenzide by differential pulse polarography.	1983 Oct	6653746
[Effect of MA-14012 (Dosetil) on lymphocyte mitogenesis. In vitro study].	1984 Jan-Feb	6146998
Pharmacokinetics and initial distribution of a new neuroleptic agent picobenzide (M-14012-4).	1985 May	2861167
'In vitro' metabolism of N-picolyl-3,5-dimethylbenzamides.	1986 Apr-Jun	3770019
Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide.	1989 Jan-Mar	2759130
Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents.	2005	16430025

Sample Use Guides

In Vivo Use Guide

Single dose - 10 mg/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:09:57 GMT 2023` Edited by `admin` on `Fri Dec 15 16:09:57 GMT 2023`
Record UNII	C46317G8F0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PICOBENZIDE

Official Name

English

3,5-DIMETHYL-N-(4-PYRIDYLMETHYL)BENZAMIDE

Systematic Name

English

picobenzide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710