Lintopride is a benzamide, eliciting prokinetic properties on the upper gut in several animal models. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animals. In canines it also increases lower oesophageal sphincter (LOS) pressure and reinforces peristaltic waves after wet swallowing, indicating a stimulatory action which could potentially be greater than that of metoclopramide. The 5HT-4 agonist lintopride increases LOS basal pressure and the amplitude of peristaltic waves of the oesophagus following a single intravenous dose in healthy subjects. The action of lintopride on LOS basal pressure and oesophageal peristaltic waves could be beneficial in patients with gastro-oesophageal reflux disease.