Domiodol is an iodinated organic compound. Domiodol had a marked cilio-excitatory effect, but did not affect experimental asthma in guinea-pigs or the respiratory resistance of anesthetized dogs. In a placebo-controlled crossover study, domiodol significantly increased the volume of secretions in chronic bronchitis subjects. This was deemed beneficial because patients were able to most easily cough up the mucus. Mucolytic treatment may be helpful in the post-operative treatment of laryngectomized patients with permanent tracheostomy. In addition, domiodol proved effective in reducing the symptoms of infection of the lower respiratory tract and in improving the consistency of mucus in children.