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Details

Stereochemistry RACEMIC
Molecular Formula C32H48N2
Molecular Weight 460.7369
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RONIPAMIL

SMILES

CCCCCCCCCCCCC(CCCN(C)CCC1=CC=CC=C1)(C#N)C2=CC=CC=C2

InChI

InChIKey=KLBJRPVUPJXXCM-UHFFFAOYSA-N
InChI=1S/C32H48N2/c1-3-4-5-6-7-8-9-10-11-18-25-32(29-33,31-22-16-13-17-23-31)26-19-27-34(2)28-24-30-20-14-12-15-21-30/h12-17,20-23H,3-11,18-19,24-28H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C32H48N2
Molecular Weight 460.7369
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Ronipamil was developed as a verapamil analogue with a longer duration of action. However, it has much less calcium antagonist action than verapamil. Ronipamil has been tested for its ability to reduce ischaemia-induced arrhythmias in conscious rats. Compared to similar compounds, ronipamil was less effective and produced no statistically significant antiarrhythmic effects in rats. It had limited haemodynamic effects and no marked actions on blood pressure and heart rate. In another study, ronipamil prolonged survival time after traumatic shock and was shown to possess anti-shock potential. No information on current development of this drug is available.

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 16:56:22 GMT 2023
Edited
by admin
on Sat Dec 16 16:56:22 GMT 2023
Record UNII
BP76593251
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RONIPAMIL
INN  
INN  
Official Name English
BENZENEACETONITRILE, .ALPHA.-DODECYL-.ALPHA.-(3-(METHYL(2-PHENYLETHYL)AMINO)PROPYL)-
Systematic Name English
ronipamil [INN]
Common Name English
(±)-2-(3-(METHYLPHENETHYLAMINO)PROPYL)-2-PHENYLTETRADECANENITRILE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29707
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
Code System Code Type Description
PUBCHEM
65638
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
INN
5545
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
FDA UNII
BP76593251
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
MESH
C045314
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
ChEMBL
CHEMBL363884
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
CAS
85247-77-4
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
NCI_THESAURUS
C74426
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
EVMPD
SUB10379MIG
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
SMS_ID
100000084358
Created by admin on Sat Dec 16 16:56:22 GMT 2023 , Edited by admin on Sat Dec 16 16:56:22 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY