MOXAZOCINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H25NO2
Molecular Weight	287.3966
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H]1[C@H]2CC3=CC=C(O)C=C3[C@]1(C)CCN2CC4CC4

InChI

InChIKey=IOZWXJXXVLARQC-SQNIBIBYSA-N

InChI=1S/C18H25NO2/c1-18-7-8-19(11-12-3-4-12)16(17(18)21-2)9-13-5-6-14(20)10-15(13)18/h5-6,10,12,16-17,20H,3-4,7-9,11H2,1-2H3/t16-,17+,18+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C18H25NO2
Molecular Weight	287.3966
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2822190 | https://www.ncbi.nlm.nih.gov/pubmed/6865909

Moxazocine is a benzomorphan derivative patented by Bristol-Myers Co. as potent opioid analgesic. Moxazocine acts as a partial agonist or mixed agonist/antagonist of the opioid receptors and binds preferentially to the κ-opioid receptor. In clinical studies, Moxazocine demonstrated superior efficacy compared morphine, but was never marketed.

Originator

Approval Year

PubMed

Title	Date	PubMed
Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to mu- and kappa-opioid receptor agonists.	1987-08	2822190

Patents

Sample Use Guides

In Vivo Use Guide

0.5 and 1.0 mg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:43:11 GMT 2025` Edited by `admin` on `Mon Mar 31 18:43:11 GMT 2025`
Record UNII	BNB57S7DWT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MOXAZOCINE

Official Name

English

LEVO-BL-4566

Preferred Name

English

2,6-METHANO-3-BENZAZOCIN-8-OL, 3-(CYCLOPROPYLMETHYL)-1,2,3,4,5,6-HEXAHYDRO-11-METHOXY-6-METHYL-, (2R-(2.ALPHA.,6.ALPHA.,11R*))-

Common Name

English

MOXAZOCINE [USAN]

Common Name

English

moxazocine [INN]

Common Name

English

(-)-(2R,6S,11R)-3-(CYCLOPROPYLMETHYL)-1,2,3,4,5,6-HEXAHYDRO-11-METHOXY-6-METHYL-2,6-METHANO-3-BENZAZOCIN-8-OL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241