Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H21N3O3 |
| Molecular Weight | 375.4204 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=C(C)C(=O)N2CC3=NC=CC=C3)C=C1C4=C(C)ON=C4C
InChI
InChIKey=YVGWSVHZXWFLIT-UHFFFAOYSA-N
InChI=1S/C22H21N3O3/c1-13-9-16-10-18(21-14(2)24-28-15(21)3)20(27-4)11-19(16)25(22(13)26)12-17-7-5-6-8-23-17/h5-11H,12H2,1-4H3
| Molecular Formula | C22H21N3O3 |
| Molecular Weight | 375.4204 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1000 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
0.6 mg/kg single, oral dose: 0.6 mg/kg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
2400 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
1.3 mg/kg single, oral dose: 1.3 mg/kg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
2000 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
1.5 mg/kg single, oral dose: 1.5 mg/kg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
2100 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
2 mg/kg single, oral dose: 2 mg/kg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
4000 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
0.6 mg/kg 1 times / day steady-state, oral dose: 0.6 mg/kg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
6000 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
1.3 mg/kg 1 times / day steady-state, oral dose: 1.3 mg/kg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
4000 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
1.5 mg/kg single, oral dose: 1.5 mg/kg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
7900 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
2 mg/kg 1 times / day steady-state, oral dose: 2 mg/kg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
2500 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
1450 ng/mL CLINICAL TRIAL https://www.nature.com/articles/s41416-020-01077-z#Sec14 |
50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered: |
ODM-207 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
| Substance Class |
Chemical
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