| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H15O3PS2 |
| Molecular Weight | 278.328 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COP(=S)(OC)OC1=CC=C(SC)C(C)=C1
InChI
InChIKey=PNVJTZOFSHSLTO-UHFFFAOYSA-N
InChI=1S/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3
| Molecular Formula | C10H15O3PS2 |
| Molecular Weight | 278.328 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Fenthion (trade names
include Baytex™, Baycid™, and
Tiguvon™, used on livestock)
was first registered domestically
in 1965 by the Mobay Corp., a
U.S. subsidiary of Bayer AG of
West Germany. Fenthion is a contact and stomach insecticide used against many sucking, biting pests, especially fruit flies, stem borers, mosquitoes, and Eurygaster cereal bugs. In mosquitoes, it is toxic to both the adult and immature forms (larvae). Once used extensively in the U.S. for controlling intestinal worms, fenthion no longer has FDA approval due to an excess number of poisoning deaths. Like most other organophosphates, its mode of action is via cholinesterase inhibition. It was used mostly for the control of grubs and lice in beef and nonlactating cattle.
Originator
Approval Year
Sample Use Guides
Beef cattle and nonlactating dairy cattle --(i) Amount. It is used at the rate of one-half fluid ounce per 100 pounds of body weight applied topically on the backline of the animal. Only one application per season should be made for grub control and this will also provide initial control of lice. A second application for lice control may be made if animals become reinfested, but no sooner than 35 days after the first treatment. The drug is a solution containing either 5.6 or 13.8 percent fenthion.
Route of Administration:
Topical
At 50 nM concentrations of fenthion the expression of Hsp89alpha
increased by approximately 4.1-fold, while the expression of
Hsp89beta increased approximately 5.3-fold, as compared to control
value. The expression of Hsp89alpha increased 5.2-fold following incubation of
cultured PC-12 cells with 100 nM concentration of fenthion, while at the same concentration the expression of Hsp89beta increased 6.8-fold as compared to control value. At 200 nM concentration of fenthion the expression of Hsp89alpha increased by approximately 5.8-fold and of
Hsp89beta increased by approximately 5.6-fold as compared to the control
value.
