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Details

Stereochemistry ACHIRAL
Molecular Formula C18H17FN4O
Molecular Weight 324.3522
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ASP-5854

SMILES

CC(C)N1C=C(C=CC1=O)C2=NC=C(N)N=C2C3=CC=C(F)C=C3

InChI

InChIKey=MNUJNGGYFNZUNB-UHFFFAOYSA-N
InChI=1S/C18H17FN4O/c1-11(2)23-10-13(5-8-16(23)24)17-18(22-15(20)9-21-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3,(H2,20,22)

HIDE SMILES / InChI

Molecular Formula C18H17FN4O
Molecular Weight 324.3522
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition.
2007 Nov
A novel adenosine A(1) and A(2A) receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: comparison with existing anti-Parkinson's disease drugs.
2008 Dec 12
Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect.
2008 Jul
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:04:49 GMT 2023
Edited
by admin
on Sat Dec 16 10:04:49 GMT 2023
Record UNII
BJS8Y4IC5V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASP-5854
Common Name English
5-(5-AMINO-3-(4-FLUOROPHENYL)-2-PYRAZINYL)-1-ISOPROPYL-2(1H)-PYRIDINONE
Systematic Name English
2(1H)-PYRIDINONE, 5-(5-AMINO-3-(4-FLUOROPHENYL)-2-PYRAZINYL)-1-(1-METHYLETHYL)-
Systematic Name English
5-(5-AMINO-3-(4-FLUOROPHENYL)PYRAZIN-2-YL)-1-ISOPROPYL-1,2-DIHYDROPYRIDIN-2-ONE
Systematic Name English
2(1H)-PYRIDINONE, 5-(5-AMINO-3-(4-FLUOROPHENYL)PYRAZINYL)-1-(1-METHYLETHYL)-
Systematic Name English
Code System Code Type Description
CAS
851087-60-0
Created by admin on Sat Dec 16 10:04:49 GMT 2023 , Edited by admin on Sat Dec 16 10:04:49 GMT 2023
PRIMARY
PUBCHEM
24810000
Created by admin on Sat Dec 16 10:04:49 GMT 2023 , Edited by admin on Sat Dec 16 10:04:49 GMT 2023
PRIMARY
FDA UNII
BJS8Y4IC5V
Created by admin on Sat Dec 16 10:04:49 GMT 2023 , Edited by admin on Sat Dec 16 10:04:49 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY