RELAMORELIN

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C43H50N8O5S
Molecular Weight	790.973
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1(CCNCC1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@@H](CC5=CSC6=C5C=CC=C6)NC(=O)C7CCNCC7

InChI

InChIKey=KUBPNVYPKPWGRJ-LIVOIKKVSA-N

InChI=1S/C43H50N8O5S/c44-42(56)43(16-20-46-21-17-43)51-41(55)34(22-27-8-2-1-3-9-27)49-39(53)35(23-29-25-47-33-12-6-4-10-31(29)33)50-40(54)36(48-38(52)28-14-18-45-19-15-28)24-30-26-57-37-13-7-5-11-32(30)37/h1-13,25-26,28,34-36,45-47H,14-24H2,(H2,44,56)(H,48,52)(H,49,53)(H,50,54)(H,51,55)/t34-,35+,36+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C43H50N8O5S
Molecular Weight	790.973
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28847163 | https://clinicaltrials.gov/ct2/show/NCT03383146 | https://www.ncbi.nlm.nih.gov/pubmed/28760384

Relamorelin (also known as BIM28131 or RM-131) is a synthetic, selective, prokinetic ghrelin analog that was developed for treatment of gastrointestinal motility disorders (such as chronic constipation and diabetic gastroparesis). Relamorelin was shown to relief symptoms such as nausea, fullness, bloating and abdominal pain. It is safe and well-tolerated in healthy individuals, and has no neurological or cardiovascular adverse effects, making this a promising drug with an advantage over other available therapies. A phase III clinical trial comparing the efficacy of relamorelin with that of placebo in participants with diabetic gastroparesis (DG) was still ongoing in 2019.

CNS Activity

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:55:15 GMT 2025` Edited by `admin` on `Mon Mar 31 21:55:15 GMT 2025`
Record UNII	BIW199E18V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

relamorelin [INN]

Preferred Name

English

RELAMORELIN

Official Name

English

4-PIPERIDINECARBOXAMIDE, 3-BENZO(B)THIEN-3-YL-N-(4-PIPERIDINYLCARBONYL)-D-ALANYL-D-TRYPTOPHYL-L-PHENYLALANYL-4-AMINO-

Systematic Name

English

Relamorelin [WHO-DD]

Common Name

English

RELAMORELIN [USAN]

Common Name

English

BIM-28131

Code

English

BIM28131

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C84868