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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H24N4O6S2
Molecular Weight 420.504
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DORIPENEM

SMILES

[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O

InChI

InChIKey=AVAACINZEOAHHE-VFZPANTDSA-N
InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1

HIDE SMILES / InChI

Molecular Formula C15H24N4O6S2
Molecular Weight 420.504
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Sources: www.fda.gov/ohrms/dockets/ac/08/briefing/2008-4364b1-02-johnson.pdf
Curator's Comment: Description was created based on several sources including http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446428/#B1

Doripenem is a synthetic carbapenem that has broad antibacterial potency against aerobic and anaerobic gram-positive and gram-negative bacteria. Doripenem is structurally related to beta-lactam antibiotics and shares the bactericidal mode of action of other β-lactam antibiotics by targeting penicillin-binding proteins (PBPs) to inhibit the biosynthesis of the bacterial cell wall. Doripenem is resistant to hydrolysis by most β-lactamases and is resistant to inactivation by renal dehydropeptidases. Doripenem has many similarities to the other carbapenems, as well as some important differences, such as greater potency against Pseudomonas aeruginosa. It was found to be similar to comparator agents. The most common adverse effects related to doripenem therapy were headache, nausea, diarrhea, rash, and phlebitis.

CNS Activity

Curator's Comment: Doripenem penetrates the intact blood-brain barrier to a small but measurable extent.

Originator

Curator's Comment: Shionogi (Japan) is the drug's originator and markets doripenem under the brand name Finibax. Peninsula Pharmaceuticals acquired development and marketing rights to doripenem in the US in a licensing agreement signed with Shionogi in 2003. Doripenem is part of Johnson &' Johnson's anti-infective R&D portfolio following the acquisition of Peninsula Pharmaceuticals in 2005.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
47.6 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
DORIBAX

Approved Use

Indicated as a single agent for the treatment of complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus and Peptostreptococcus micros and as a single agent for the treatment of complicated urinary tract infections, including pyelonephritis caused by Escherichia coli including cases with concurrent bacteremia, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii. To reduce the development of drug-resistant bacteria and maintain the effectiveness of DORIBAX® and other antibacterial drugs, DORIBAX® should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.

Launch Date

2007
Curative
DORIBAX

Approved Use

Indicated as a single agent for the treatment of complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus and Peptostreptococcus micros and as a single agent for the treatment of complicated urinary tract infections, including pyelonephritis caused by Escherichia coli including cases with concurrent bacteremia, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii. To reduce the development of drug-resistant bacteria and maintain the effectiveness of DORIBAX® and other antibacterial drugs, DORIBAX® should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.

Launch Date

2007
Curative
DORIBAX

Approved Use

Indicated as a single agent for the treatment of complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus and Peptostreptococcus micros and as a single agent for the treatment of complicated urinary tract infections, including pyelonephritis caused by Escherichia coli including cases with concurrent bacteremia, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii. To reduce the development of drug-resistant bacteria and maintain the effectiveness of DORIBAX® and other antibacterial drugs, DORIBAX® should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.

Launch Date

2007
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
16.87 μg/mL
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
12.94 μg/mL
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
10.2 mg/L
250 mg single, intravenous
dose: 250 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
23 μg/mL
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
52.98 μg × h/mL
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
70.64 μg × h/mL
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
13.8 mg × h/L
250 mg single, intravenous
dose: 250 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
36.3 μg × h/mL
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
47.1 mg*h/L
500 mg 1 times / 8 hour multiple, intravenous
dose: 500 mg
route of administration: intravenous
experiment type: multiple
co-administered:
DORIPENEM serum
Homo sapiens
population: unhealthy
age:
sex:
food status:
66.4 mg*h/L
1000 mg 1 times / 8 hour multiple, intravenous
dose: 1000 mg
route of administration: intravenous
experiment type: multiple
co-administered:
DORIPENEM serum
Homo sapiens
population: unhealthy
age:
sex:
food status:
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.93 h
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.04 h
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.91 h
250 mg single, intravenous
dose: 250 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1 h
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
2.2 h
500 mg 1 times / 8 hour multiple, intravenous
dose: 500 mg
route of administration: intravenous
experiment type: multiple
co-administered:
DORIPENEM serum
Homo sapiens
population: unhealthy
age:
sex:
food status:
2.4 h
1000 mg 1 times / 8 hour multiple, intravenous
dose: 1000 mg
route of administration: intravenous
experiment type: multiple
co-administered:
DORIPENEM serum
Homo sapiens
population: unhealthy
age:
sex:
food status:
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
91.9%
500 mg single, intravenous
dose: 500 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DORIPENEM plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Disc. AE: Transaminases increased, Allergic reaction...
Other AEs: Leukopenia, Diarrhea...
AEs leading to
discontinuation/dose reduction:
Transaminases increased (1 patient)
Allergic reaction (1 patient)
Other AEs:
Leukopenia (1 patient)
Diarrhea (11 patient)
Nausea (9 patients)
Vomiting (9 patients)
Headache (6 patients)
Oral candidiasis (3 patients)
Rash (2 patients)
Sources:
500 mg 3 times / day steady, intravenous
Recommended
Dose: 500 mg, 3 times / day
Route: intravenous
Route: steady
Dose: 500 mg, 3 times / day
Sources:
unhealthy, 54 years (range: 18-90 years)
n = 853
Health Status: unhealthy
Condition: intra-abdominal infections
Age Group: 54 years (range: 18-90 years)
Sex: M+F
Population Size: 853
Sources:
Disc. AE: Nausea, Vulval mycotic infection...
AEs leading to
discontinuation/dose reduction:
Nausea (0.2%)
Vulval mycotic infection (0.1%)
Rash (0.1%)
Sources:
5 mg/kg single, intravenous
Dose: 5 mg/kg
Route: intravenous
Route: single
Dose: 5 mg/kg
Sources:
unknown, <8 weeks
n = 26
Health Status: unknown
Age Group: <8 weeks
Sex: M+F
Population Size: 26
Sources:
Other AEs: Anemia neonatal, Hypoalbuminemia...
Other AEs:
Anemia neonatal (3 patients)
Hypoalbuminemia (3 patients)
Hyperglycemia (2 patients)
Peripheral edema (1 patient)
Patent ductus arteriosus (2 patients)
Sources:
8 mg/kg single, intravenous
Dose: 8 mg/kg
Route: intravenous
Route: single
Dose: 8 mg/kg
Sources:
unknown, >8 weeks <44 weeks
n = 26
Health Status: unknown
Age Group: >8 weeks <44 weeks
Sex: M+F
Population Size: 26
Sources:
Other AEs: Anemia neonatal, Peripheral edema...
Other AEs:
Anemia neonatal (1 patient)
Peripheral edema (1 patient)
Dermatitis diaper (2 patients)
Sources:
AEs

AEs

AESignificanceDosePopulation
Leukopenia 1 patient
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Allergic reaction 1 patient
Disc. AE
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Transaminases increased 1 patient
Disc. AE
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Diarrhea 11 patient
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Rash 2 patients
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Oral candidiasis 3 patients
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Headache 6 patients
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Nausea 9 patients
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Vomiting 9 patients
2 g 3 times / day multiple, intravenous
Highest studied dose
Dose: 2 g, 3 times / day
Route: intravenous
Route: multiple
Dose: 2 g, 3 times / day
Sources:
unhealthy, 24 years (rangeL 21–37 years)
n = 16
Health Status: unhealthy
Condition: cystic fibrosis
Age Group: 24 years (rangeL 21–37 years)
Sex: M+F
Population Size: 16
Sources:
Rash 0.1%
Disc. AE
500 mg 3 times / day steady, intravenous
Recommended
Dose: 500 mg, 3 times / day
Route: intravenous
Route: steady
Dose: 500 mg, 3 times / day
Sources:
unhealthy, 54 years (range: 18-90 years)
n = 853
Health Status: unhealthy
Condition: intra-abdominal infections
Age Group: 54 years (range: 18-90 years)
Sex: M+F
Population Size: 853
Sources:
Vulval mycotic infection 0.1%
Disc. AE
500 mg 3 times / day steady, intravenous
Recommended
Dose: 500 mg, 3 times / day
Route: intravenous
Route: steady
Dose: 500 mg, 3 times / day
Sources:
unhealthy, 54 years (range: 18-90 years)
n = 853
Health Status: unhealthy
Condition: intra-abdominal infections
Age Group: 54 years (range: 18-90 years)
Sex: M+F
Population Size: 853
Sources:
Nausea 0.2%
Disc. AE
500 mg 3 times / day steady, intravenous
Recommended
Dose: 500 mg, 3 times / day
Route: intravenous
Route: steady
Dose: 500 mg, 3 times / day
Sources:
unhealthy, 54 years (range: 18-90 years)
n = 853
Health Status: unhealthy
Condition: intra-abdominal infections
Age Group: 54 years (range: 18-90 years)
Sex: M+F
Population Size: 853
Sources:
Peripheral edema 1 patient
5 mg/kg single, intravenous
Dose: 5 mg/kg
Route: intravenous
Route: single
Dose: 5 mg/kg
Sources:
unknown, <8 weeks
n = 26
Health Status: unknown
Age Group: <8 weeks
Sex: M+F
Population Size: 26
Sources:
Hyperglycemia 2 patients
5 mg/kg single, intravenous
Dose: 5 mg/kg
Route: intravenous
Route: single
Dose: 5 mg/kg
Sources:
unknown, <8 weeks
n = 26
Health Status: unknown
Age Group: <8 weeks
Sex: M+F
Population Size: 26
Sources:
Patent ductus arteriosus 2 patients
5 mg/kg single, intravenous
Dose: 5 mg/kg
Route: intravenous
Route: single
Dose: 5 mg/kg
Sources:
unknown, <8 weeks
n = 26
Health Status: unknown
Age Group: <8 weeks
Sex: M+F
Population Size: 26
Sources:
Anemia neonatal 3 patients
5 mg/kg single, intravenous
Dose: 5 mg/kg
Route: intravenous
Route: single
Dose: 5 mg/kg
Sources:
unknown, <8 weeks
n = 26
Health Status: unknown
Age Group: <8 weeks
Sex: M+F
Population Size: 26
Sources:
Hypoalbuminemia 3 patients
5 mg/kg single, intravenous
Dose: 5 mg/kg
Route: intravenous
Route: single
Dose: 5 mg/kg
Sources:
unknown, <8 weeks
n = 26
Health Status: unknown
Age Group: <8 weeks
Sex: M+F
Population Size: 26
Sources:
Anemia neonatal 1 patient
8 mg/kg single, intravenous
Dose: 8 mg/kg
Route: intravenous
Route: single
Dose: 8 mg/kg
Sources:
unknown, >8 weeks <44 weeks
n = 26
Health Status: unknown
Age Group: >8 weeks <44 weeks
Sex: M+F
Population Size: 26
Sources:
Peripheral edema 1 patient
8 mg/kg single, intravenous
Dose: 8 mg/kg
Route: intravenous
Route: single
Dose: 8 mg/kg
Sources:
unknown, >8 weeks <44 weeks
n = 26
Health Status: unknown
Age Group: >8 weeks <44 weeks
Sex: M+F
Population Size: 26
Sources:
Dermatitis diaper 2 patients
8 mg/kg single, intravenous
Dose: 8 mg/kg
Route: intravenous
Route: single
Dose: 8 mg/kg
Sources:
unknown, >8 weeks <44 weeks
n = 26
Health Status: unknown
Age Group: >8 weeks <44 weeks
Sex: M+F
Population Size: 26
Sources:
Overview

Overview

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
no
no
no
no
no
unlikely
unlikely
unlikely
unlikely
unlikely
unlikely
Drug as victim

Drug as victim

Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Sources: www.accessdata.fda.gov/drugsatfda_docs/label/2013/022106s014lbl.pdf
Curator's Comment: Administered every 8 hours by intravenous infusion over one hour in patients ≥18 years of age. For complicated intra-abdominal infection 5-14 days, for complicated UTI, including pyelonephritis 10 days.
500 mg administered every 8 hours by intravenous infusion over one hour in patients ≥18 years of age; for complicated intra-abdominal infection 5–14 days, for complicated UTI, including pyelonephritis 10 days.
Route of Administration: Intravenous
In Vitro Use Guide
Sources: www.accessdata.fda.gov/cdrh_docs/reviews/k080019.pdf
HardyDisk™ Doripenem Antimicrobial Susceptibility Test Disks are used for semi-quantitative in vitro susceptibility testing by the agar diffusion test procedure (Kirby-Bauer) of rapidly growing and certain fastidious bacterial pathogens. The concentration of doripenem 10ug has been shown to be active against most isolates of the following microorganisms both in vitro and in clinical infections: Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Streptococcus constellatus, Streptococcus intermedius
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:03:18 GMT 2023
Edited
by admin
on Fri Dec 15 16:03:18 GMT 2023
Record UNII
BHV525JOBH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DORIPENEM
DASH   EMA EPAR   INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
DORIPENEM [EMA EPAR]
Common Name English
DORIPENEM [MART.]
Common Name English
doripenem [INN]
Common Name English
DORIPENEM [USAN]
Common Name English
1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID, 3-(((3S,5S)-5-(((AMINOSULFONYL)AMINO)METHYL)-3-PYRROLIDINYL)THIO)-6-((1R)-1-HYDROXYETHYL)-4-METHYL-7-OXO-, (4R,5S,6S)-
Common Name English
(+)-(4R,5S,6S)-6-((1R)-1-HYDROXYETHYL)-4-METHYL-7-OXO-3-(((3S,5S)-5-((SULFAMOYLAMINO)METHYL)-3-PYRROLIDINYL)THIO)-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID
Systematic Name English
DORIPENEM [VANDF]
Common Name English
DORIBAX
Brand Name English
DORIPENEM [ORANGE BOOK]
Common Name English
Doripenem [WHO-DD]
Common Name English
S-4661
Code English
DORIPENEM [MI]
Common Name English
Classification Tree Code System Code
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000175496
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NCI_THESAURUS C260
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
EMA ASSESSMENT REPORTS DORIBAX (WITHDRAW: URINARY TRACT INFECTIONS)
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
FDA ORPHAN DRUG 188104
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
WHO-ATC J01DH04
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
NDF-RT N0000011294
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
LIVERTOX NBK548111
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
WHO-VATC QJ01DH04
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
Code System Code Type Description
MESH
C099245
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
NCI_THESAURUS
C65470
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID2046678
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
FDA UNII
BHV525JOBH
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
DRUG CENTRAL
4149
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
DRUG BANK
DB06211
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
MERCK INDEX
m4744
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY Merck Index
USAN
RR-37
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
EVMPD
SUB22196
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
ChEMBL
CHEMBL491571
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
CAS
148016-81-3
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
LACTMED
Doripenem
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
RXCUI
119771
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY RxNorm
PUBCHEM
73303
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
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INN
7975
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
SMS_ID
100000089808
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
WIKIPEDIA
DORIPENEM
Created by admin on Fri Dec 15 16:03:18 GMT 2023 , Edited by admin on Fri Dec 15 16:03:18 GMT 2023
PRIMARY
Related Record Type Details
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
SOLVATE->ANHYDROUS
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
SALT/SOLVATE -> PARENT
TARGET ORGANISM->INHIBITOR
TARGET ORGANISM->INHIBITOR
Related Record Type Details
METABOLITE INACTIVE -> PARENT
primarily via dehydropeptidase-I
MAJOR
PLASMA; URINE
Related Record Type Details
ACTIVE MOIETY