Details
| Stereochemistry | MIXED |
| Molecular Formula | C16H12ClNOS |
| Molecular Weight | 301.791 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC12N=C(SC1CC3=C2C=CC(Cl)=C3)C4=CC=CC=C4
InChI
InChIKey=RUBKYBIDEVUTQU-UHFFFAOYSA-N
InChI=1S/C16H12ClNOS/c17-12-6-7-13-11(8-12)9-14-16(13,19)18-15(20-14)10-4-2-1-3-5-10/h1-8,14,19H,9H2
| Molecular Formula | C16H12ClNOS |
| Molecular Weight | 301.791 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:41:38 GMT 2023
by
admin
on
Fri Dec 15 16:41:38 GMT 2023
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| Record UNII |
BD22Q5WK25
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| Record Status |
Validated (UNII)
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| Record Version |
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262376-75-0
Created by
admin on Fri Dec 15 16:41:38 GMT 2023 , Edited by admin on Fri Dec 15 16:41:38 GMT 2023
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BD22Q5WK25
Created by
admin on Fri Dec 15 16:41:38 GMT 2023 , Edited by admin on Fri Dec 15 16:41:38 GMT 2023
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782482-03-5
Created by
admin on Fri Dec 15 16:41:38 GMT 2023 , Edited by admin on Fri Dec 15 16:41:38 GMT 2023
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DTXSID9047338
Created by
admin on Fri Dec 15 16:41:38 GMT 2023 , Edited by admin on Fri Dec 15 16:41:38 GMT 2023
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9882837
Created by
admin on Fri Dec 15 16:41:38 GMT 2023 , Edited by admin on Fri Dec 15 16:41:38 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
HMR1426 inhibited feed consumption dose-dependently in rodents. We proved that HMR1426 is not a CCK(A) agonist. The correlation between anorectic properties of HMR1426 and gastric emptying suggests that gastric emptying may cause the anorectic properties of HMR1426. The differences in microstructural feeding behavior between HMR1426 and centrally active anorectics makes it unlikely that HMR1426 acts via the CNS.
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ACTIVE MOIETY |
HMR1426 (50 mg/kg) caused an acute and chronic decrease of food intake. There was no effect on the level and daily pattern of total energy expenditure, Tb, and locomotor activity.
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