ADAFENOXATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H26ClNO3
Molecular Weight	363.878
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(OCC(=O)OCCNC23CC4CC(CC(C4)C2)C3)C=C1

InChI

InChIKey=PLSMXIQMWYSHIV-UHFFFAOYSA-N

InChI=1S/C20H26ClNO3/c21-17-1-3-18(4-2-17)25-13-19(23)24-6-5-22-20-10-14-7-15(11-20)9-16(8-14)12-20/h1-4,14-16,22H,5-13H2

HIDE SMILES / InChI

Molecular Formula	C20H26ClNO3
Molecular Weight	363.878
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8412411 | https://www.ncbi.nlm.nih.gov/pubmed/1667717 | https://www.ncbi.nlm.nih.gov/pubmed/2896427 | https://www.ncbi.nlm.nih.gov/pubmed/7835648 | https://www.ncbi.nlm.nih.gov/pubmed/7835647 | https://www.ncbi.nlm.nih.gov/pubmed/1662175 | https://www.ncbi.nlm.nih.gov/pubmed/2576744

Adafenoxate exerts nootropic and anxiolytic properties in rodents. Adafenoxate inhibits monoamine oxidase and cAMP phosphodiesterase activity. Adafenoxate inhibits monoamine uptake and regulates the density of the 5-HT1 sites in the brain.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in rats.	1989 Sep	2511850

Sample Use Guides

In Vivo Use Guide

mice: i.p. 50 and 100 mg/kg once daily for 7 days rats: p.o. 100 mg/kg for 5 days

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:41:06 GMT 2023` Edited by `admin` on `Fri Dec 15 15:41:06 GMT 2023`
Record UNII	B8VQU4C05J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADAFENOXATE

Official Name

English

2-(1-ADAMANTYLAMINO)ETHYL (P-CHLOROPHENOXY)ACETATE

Common Name

English

adafenoxate [INN]

Common Name

English

ACETIC ACID, 2-(4-CHLOROPHENOXY)-, 2-(TRICYCLO(3.3.1.13,7)DEC-1-YLAMINO)ETHYL ESTER

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265