IOMAZENIL I-123

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14IN3O3
Molecular Weight	407.1956
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C2CN(C)C(=O)C3=C([123I])C=CC=C3N2C=N1

InChI

InChIKey=FRIZVHMAECRUBR-KIWWSDKQSA-N

InChI=1S/C15H14IN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3/i16-4

HIDE SMILES / InChI

Molecular Formula	C15H14IN3O3
Molecular Weight	407.1956
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/books/NBK23489/
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/12605353

[123I]Iomazenil ([123I] IMZ) is a ligand displaying high affinity for central-type benzodiazepine receptors. It is a useful marker of neuronal viability. [123I]IMZ has been successfully used as a probe for single photon emission computed tomography (SPECT) in numerous clinical studies of diseases and also itcan be used to image epileptic seizure foci. 123I-iomazenil is rapidly metabolized and more than 90% of the administrated radioactivity was excreted within the first 24 hr. Dominant metabolites were acid metabolite (R-COOH), glucuronide of the acid (R-COOH-Glc) and free iodide (I-). Metabolites of 123I-iomazenil do not cross the blood-brain barrier. [123I]IMZ is readily available commercially.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; GABA-A site (alpha1/beta2 interface) 2 Target ID: CHEMBL1907597 Sources: http://www.ncbi.nlm.nih.gov/pubmed/26909048	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mental disorders 3 Sources: http://www.ncbi.nlm.nih.gov/pubmed/9460528	Diagnostic		Preclinical	Unknown Approved Use Unknown
Panic disorder 24 Sources: http://www.ncbi.nlm.nih.gov/pubmed/10664825	Diagnostic		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Radiopharmaceuticals for single-photon emission computed tomography brain imaging.	2003-01	12605353

Patents

Sample Use Guides

In Vivo Use Guide

bolus i.v. injection of 167 MBq

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:37:06 GMT 2025` Edited by `admin` on `Wed Apr 02 09:37:06 GMT 2025`
Record UNII	B851121553
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IOMAZENIL I-123

Common Name

English

IOMAZENIL (123I)

Preferred Name

English

IOMAZENIL (123I) [JAN]

Common Name

English

IOMAZENIL (123I) [MI]

Common Name

English

Iomazenil (123I) [WHO-DD]

Common Name

English

ETHYL 5,6-DIHYDRO-7-IODO-(SUP 123 SUP)I-5-METHYL-6-OXO-4H-IMIDAZO(1,5-A)(1,4)BENZODIAZEPINE-3-CARBOXYLATE

Common Name

English

IOMAZENIL, I-123

Common Name

English

iomazenil (¹²³I) [INN]

Common Name

English

IOMAZENIL (123 I)

Common Name

English

IOMAZENIL I 123

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124