Tezemlimogene Daxadenorepvec

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 18:38:27 UTC 2023` Edited by `admin` on `Sat Dec 16 18:38:27 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT VIRUS
Source Materials State	CONDITIONALLY REPLICATIVE, GENETICALLY MODIFIED
Organism Family	Adenoviridae
Organism Genus	Mastadenovirus
Organism Species	human mastadenovirus d
Author	NONE
Infraspecific Type	RECOMBINANT VECTOR
Infraspecific Name	AdV serotype 5-deletion of 24 bp (bases 923-946) from E1A gene-insertion of an integrin-binding motif (RGD-4C) in H1-CMV-human OX40-BGHpA in AdV E3
Part	whole
Record UNII	B7N7BR6M4A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tezemlimogene Daxadenorepvec

Official Name

English

tezemlimogene daxadenorepvec [INN]

Common Name

English

recombinant conditionally replication-competent oncolytic adenovirus type 5 (Ad5) encoding human immune modulatory protein OX40 ligand (OX40L, CD252, tumor necrosis factor ligand superfamily member 4) under control of the cytomegalovirus (CMV) immediate-

Common Name

English

DNA (recombinant human adenovirus 5 ΔE1AΔE3 vector DNX-2440 simian cytomegalovirus immediate-early promoter-enhancer plus human OX40 ligand gene plus Bos taurus growth hormone polyadenylation signal plus viral fiber protein RGD motif insertion mutein-s

Common Name

English

DNX-2440

Code

English

Code System Code Type Description

INN

12282

Created by admin on Sat Dec 16 18:38:27 UTC 2023 , Edited by admin on Sat Dec 16 18:38:27 UTC 2023

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CAS

2642046-11-3

Created by admin on Sat Dec 16 18:38:27 UTC 2023 , Edited by admin on Sat Dec 16 18:38:27 UTC 2023

PRIMARY

FDA UNII

B7N7BR6M4A

Created by admin on Sat Dec 16 18:38:27 UTC 2023 , Edited by admin on Sat Dec 16 18:38:27 UTC 2023

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NCI_THESAURUS

C160192

Created by admin on Sat Dec 16 18:38:27 UTC 2023 , Edited by admin on Sat Dec 16 18:38:27 UTC 2023

PRIMARY

Related Record Type Details


					B7N7BR6M4A

Tezemlimogene Daxadenorepvec

ACTIVE MOIETY

Comments:

The direct oncolytic activity and anti-tumor immune activity of DNX-2440 is expected to be similar to DNX-2401 with augmented immune activation due to the local expression of OX40L within the tumor.

Amount:

Structural Modifications

Modification Type	Fragment Name	Fragment Approval
GENE DISRUPTION	UNSPECIFIED SUBSTANCE	c751c9d8 (not in database)
GENE DELETION	ADENOVIRUS 5 E3 GENE	A62MKE7J2U
INSERTED GENE EXPRESSION VECTOR	Tezemlimogene daxadenorepvec transgene insert	XDC9U7Z96A