Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Wed Apr 02 11:51:58 GMT 2025
by
admin
on
Wed Apr 02 11:51:58 GMT 2025
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| Source Materials Class | ORGANISM |
| Source Materials Type | RECOMBINANT VIRUS |
| Source Materials State | CONDITIONALLY REPLICATIVE, GENETICALLY MODIFIED |
| Organism Family | Adenoviridae |
| Organism Genus | Mastadenovirus |
| Organism Species | human mastadenovirus d |
| Author | NONE |
| Infraspecific Type | RECOMBINANT VECTOR |
| Infraspecific Name | AdV serotype 5-deletion of 24 bp (bases 923-946) from E1A gene-insertion of an integrin-binding motif (RGD-4C) in H1-CMV-human OX40-BGHpA in AdV E3 |
| Part | whole |
| Record UNII |
B7N7BR6M4A
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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12282
Created by
admin on Wed Apr 02 11:51:58 GMT 2025 , Edited by admin on Wed Apr 02 11:51:58 GMT 2025
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PRIMARY | |||
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2642046-11-3
Created by
admin on Wed Apr 02 11:51:58 GMT 2025 , Edited by admin on Wed Apr 02 11:51:58 GMT 2025
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300000047294
Created by
admin on Wed Apr 02 11:51:58 GMT 2025 , Edited by admin on Wed Apr 02 11:51:58 GMT 2025
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PRIMARY | |||
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B7N7BR6M4A
Created by
admin on Wed Apr 02 11:51:58 GMT 2025 , Edited by admin on Wed Apr 02 11:51:58 GMT 2025
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PRIMARY | |||
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C160192
Created by
admin on Wed Apr 02 11:51:58 GMT 2025 , Edited by admin on Wed Apr 02 11:51:58 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
The direct oncolytic activity and anti-tumor immune activity of DNX-2440 is expected to be similar to DNX-2401 with augmented immune activation due to the local expression of OX40L within the tumor.
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| GENE DISRUPTION | UNSPECIFIED SUBSTANCE |
c751c9d8
(not in database)
|
||||
| GENE DELETION | ADENOVIRUS 5 E3 GENE | A62MKE7J2U | ||||
| INSERTED GENE EXPRESSION VECTOR | Tezemlimogene daxadenorepvec transgene insert | XDC9U7Z96A |