U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C13H11N3O5S
Molecular Weight 321.309
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SALAZOSULFAMIDE

SMILES

NS(=O)(=O)C1=CC=C(C=C1)\N=N\C2=CC(C(O)=O)=C(O)C=C2

InChI

InChIKey=NBSRUZQXRUNPNY-FOCLMDBBSA-N
InChI=1S/C13H11N3O5S/c14-22(20,21)10-4-1-8(2-5-10)15-16-9-3-6-12(17)11(7-9)13(18)19/h1-7,17H,(H,18,19)(H2,14,20,21)/b16-15+

HIDE SMILES / InChI

Molecular Formula C13H11N3O5S
Molecular Weight 321.309
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Salazosulfamide was studied for the treatment of ankylosing spondylitis. It was found that salazosulfamide efficacy is associated with N-acetyltransferase 1 polymorphisms and in particularly, NAT1 AA/GG genotype at 263 locus. However, future studies should be conducted to investigate these issues.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
The experimental group received 7.5 mg of salazosulfamide (MTX) per week
Route of Administration: Oral
Substance Class Chemical
Record UNII
B6831ORH7W
Record Status Validated (UNII)
Record Version