Tilivapram

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H15Cl2N3O4
Molecular Weight	384.214
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of Tilivapram

Structure Search

SMILES

COC1=C(OCC2CC2)C=C(N=C1)C(=O)NC3=C(Cl)C=[N+]([O-])C=C3Cl

InChI

InChIKey=BRUDLLFMCVQZFT-UHFFFAOYSA-N

InChI=1S/C16H15Cl2N3O4/c1-24-14-5-19-12(4-13(14)25-8-9-2-3-9)16(22)20-15-10(17)6-21(23)7-11(15)18/h4-7,9H,2-3,8H2,1H3,(H,20,22)

HIDE SMILES / InChI

Molecular Formula	C16H15Cl2N3O4
Molecular Weight	384.214
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19950209&CC=WO&NR=9504045A1&KC=A1

Tilivapram is a heterocyclylbenzamide derivative patented by Rhone-Poulenc Rorer Ltd as phosphodiesterase IV inhibitor.

Originator

Approval Year

Patents

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:45:22 GMT 2025` Edited by `admin` on `Mon Mar 31 18:45:22 GMT 2025`
Record UNII	B5983P6VWM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tilivapram

Official Name

English

tilivapram [INN]

Preferred Name

English

2-Pyridinecarboxamide, 4-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-5-methoxy-

Systematic Name

English

4-(4-(CYCLOPROPYLMETHOXY)-5-METHOXYPYRIDINE-2-CARBOXAMIDO)-3,5-DICHLOROPYRIDINE 1-OXIDE

Systematic Name

English

4-(Cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-5-methoxy-2-pyridinecarboxamide

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

Code System Code Type Description

SMS_ID

300000036848

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

PRIMARY

NCI_THESAURUS

C152630

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

PRIMARY

INN

9075

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

PRIMARY

CAS

166741-91-9

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

PRIMARY

PUBCHEM

25054908

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

PRIMARY

FDA UNII

B5983P6VWM

Created by admin on Mon Mar 31 18:45:22 GMT 2025 , Edited by admin on Mon Mar 31 18:45:22 GMT 2025

PRIMARY

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