ASAPIPRANT

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H27N3O7S
Molecular Weight	501.552
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)OC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=CC=C(C4=NC=CO4)C(OCC(O)=O)=C3

InChI

InChIKey=ZMZNWNTZRWXTJU-UHFFFAOYSA-N

InChI=1S/C24H27N3O7S/c1-17(2)34-19-4-6-20(7-5-19)35(30,31)27-12-10-26(11-13-27)18-3-8-21(24-25-9-14-32-24)22(15-18)33-16-23(28)29/h3-9,14-15,17H,10-13,16H2,1-2H3,(H,28,29)

HIDE SMILES / InChI

Molecular Formula	C24H27N3O7S
Molecular Weight	501.552
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26277322 | https://adisinsight.springer.com/drugs/800027674 | https://clinicaltrials.gov/ct2/show/NCT01651871

Asapiprant, also known as S-555739, a selective Prostaglandin D2 receptor 1 antagonist, participated in phase III of clinical trials in Japan and in phase II of trials in the USA for patients with Allergic rhinitis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostanoid DP receptor 16 Target ID: CHEMBL4427 Sources: https://adisinsight.springer.com/drugs/800027674\|https://www.ncbi.nlm.nih.gov/pubmed/26277322	Antagonist 2849		0.44 nM [Ki]

PubMed

Title	Date	PubMed
Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma.	2015-10-15	26277322

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:00:18 GMT 2025` Edited by `admin` on `Mon Mar 31 21:00:18 GMT 2025`
Record UNII	B2LW71CRGL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

asapiprant [INN]

Preferred Name

English

ASAPIPRANT

Official Name

English

S-555739

Common Name

English

ACETIC ACID, 2-(5-(4-((4-(1-METHYLETHOXY)PHENYL)SULFONYL)-1-PIPERAZINYL)-2-(2-OXAZOLYL)PHENOXY)-

Systematic Name

English

BGE175

Code

English

2-(2-(OXAZOL-2-YL)-5-(4-(4-((PROPAN-2-YL)OXY)BENZENESULFONYL(PIPERAZIN-1-YL)PHENOXY)ACETIC ACID

Systematic Name

English

BGE 175 [WHO-DD]

Common Name

English

BGE-175

Code

English

Code System Code Type Description

NCI_THESAURUS

C171866