.BETA.-BOSWELLIC ACID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H48O3
Molecular Weight	456.7003
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2[C@H]1C

InChI

InChIKey=NBGQZFQREPIKMG-PONOSELZSA-N

InChI=1S/C30H48O3/c1-18-10-13-26(3)16-17-28(5)20(24(26)19(18)2)8-9-21-27(4)14-12-23(31)30(7,25(32)33)22(27)11-15-29(21,28)6/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21-,22-,23-,24+,26-,27-,28-,29-,30-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C30H48O3
Molecular Weight	456.7003
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27646163 | https://www.ncbi.nlm.nih.gov/pubmed/27460774

Β-boswellic acid (β-BA) is one of the active triterpenoid compounds from the extract of boswellia serrate, known in Indian Ayurvedic system of medicine as Salai guggal. Beta-boswellic acid has been indicated in apoptosis of cancer cells. β-boswellic acid belonds to class of boswellic acids exhibiting anti-inflammatory activities, which are in the phase II clinical trial for study of safety and tolerability in subjects with Relapsing Remitting Multiple Sclerosis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Arachidonate 5-lipoxygenase 52 Target ID: CHEMBL215 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19374837	Inhibitor 8504		23.9 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Relapsing-remitting multiple sclerosis 8 Sources: https://clinicaltrials.gov/ct2/show/NCT01450124	Palliative		Phase II 1147	Unknown Approved Use Unknown
Cancer 609 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27458759	Primary		Preclinical	Unknown Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
1.244 μg/mL EXPERIMENT https://www.sciencedirect.com/science/article/abs/pii/S0944711304703256	333 mg single, oral dose: 333 mg route of administration: Oral experiment type: SINGLE co-administered:		Β-BOSWELLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED

AUC

Value	Dose	Co-administered	Analyte	Population
12.48 μg × h/mL EXPERIMENT https://www.sciencedirect.com/science/article/abs/pii/S0944711304703256	333 mg single, oral dose: 333 mg route of administration: Oral experiment type: SINGLE co-administered:		Β-BOSWELLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.35 h EXPERIMENT https://www.sciencedirect.com/science/article/abs/pii/S0944711304703256	333 mg single, oral dose: 333 mg route of administration: Oral experiment type: SINGLE co-administered:		Β-BOSWELLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FED

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY100738	https://www.001chemical.com/chem/search?q=DY100738
1PlusChem LLC	1P003P0D	https://www.1pchem.com/search?query=1P003P0D
AK Scientific	X1097	https://aksci.com/item_detail.php?cat=X1097
Alfa Chemistry	198597	http://www.alfa-chemistry.com/search.aspx?q=198597
Alfa Chemistry	ACM631696	http://www.alfa-chemistry.com/search.aspx?q=ACM631696
AstaTech	43621	http://astatechinc.com/CPSResult.php?CRNO=43621
Biopurify Phytochemicals	BP0261	https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP0261&searchhtmp=simplesearch&t=1
Chem Scene	CS-0022784	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0022784
eMolecules	30512797	https://orderbb.emolecules.com/search/#?query=30512797
eMolecules	31225009	https://orderbb.emolecules.com/search/#?query=31225009
Indofine	20036	https://indofinechemical.com/details.aspx?Sku=020036
Matrix Scientific	99240	http://www.matrixscientific.com/099240.html
mcule	MCULE-5384515579	https://mcule.com/MCULE-5384515579/
MedChem Express	HY-N2513	https://www.medchemexpress.com/search.html?q=HY-N2513&ft=&fa=&fp=
Molcore	MC100738	http://www.molcore.com/CatMC100738.html
MolPort	MolPort-006-069-379	https://www.molport.com/shop/molecule-link/MolPort-006-069-379
Tetrahedron	TS71987	http://www.thsci.com/search.do?q=TS71987
Toronto Research Chemicals	B676500	https://www.trc-canada.com/product-detail/?CatNum=B676500

PubMed

Title	Date	PubMed
Effects of Boswellia serrata in mouse models of chemically induced colitis.	2005-04	15539433
Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.	2002-12	12507932
Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.	1998-11-17	9810030
Mechanism of antiinflammatory actions of curcumine and boswellic acids.	1993-03	8510458

Patents

Sample Use Guides

In Vivo Use Guide

8 months of treatment at three times a day dose of between 400-1600 mg

Route of Administration: Oral

In Vitro Use Guide

β-boswellic acid (β-BA) significantly increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs). HEUVCs were pretreated with β-BA (25 and 50 uM) for 24 h before being subjected to 6 h OGD then incubated with β-BA for an additional 24 h. NO production was measured by DAF-FM DA. The amount of NO was evaluated by measuring the fluorescence intensity excited at 495 nm and emitted at 515 nm.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:26:24 GMT 2025` Edited by `admin` on `Mon Mar 31 21:26:24 GMT 2025`
Record UNII	B252M1YO2V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

.BETA.-BOSWELLIC ACID (CONSTITUENT OF BOSWELLIA SERRATA) [DSC]

Preferred Name

English

.BETA.-BOSWELLIC ACID

Common Name

English

URS-12-EN-24-OIC ACID, 3.ALPHA.-HYDROXY-

Common Name

English

3.ALPHA.-HYDROXYURS-12-EN-24-OIC ACID

Common Name

English

BETA-BOSWELLIC ACID

Common Name

English

URS-12-EN-23-OIC ACID, 3-HYDROXY-, (3.ALPHA.,4.BETA.)-

Common Name

English

.BETA.-BOSWELLIC ACID [MI]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID2057578