CFT-8634

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C37H45F3N6O5
Molecular Weight	710.7856
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(=CC(OC)=C1CN2CC[C@H](N3CCN(CC3)C4=CC=C(N[C@H]5CCC(=O)NC5=O)C=C4F)C(F)(F)C2)C6=CN(C)C(=O)C(C)=C6C

InChI

InChIKey=GNRGNRCQXHMQQV-ZQAZVOLISA-N

InChI=1S/C37H45F3N6O5/c1-22-23(2)36(49)43(3)19-26(22)24-16-31(50-4)27(32(17-24)51-5)20-44-11-10-33(37(39,40)21-44)46-14-12-45(13-15-46)30-8-6-25(18-28(30)38)41-29-7-9-34(47)42-35(29)48/h6,8,16-19,29,33,41H,7,9-15,20-21H2,1-5H3,(H,42,47,48)/t29-,33-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C37H45F3N6O5
Molecular Weight	710.7856
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:50:34 GMT 2023` Edited by `admin` on `Sat Dec 16 18:50:34 GMT 2023`
Record UNII	AW8PEP3VZ3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CFT-8634

Code

English

CFT8634

Code

English

2,6-PIPERIDINEDIONE, 3-((4-(4-((4S)-1-((4-(1,6-DIHYDRO-1,4,5-TRIMETHYL-6-OXO-3-PYRIDINYL)-2,6-DIMETHOXYPHENYL)METHYL)-3,3-DIFLUORO-4-PIPERIDINYL)-1-PIPERAZINYL)-3-FLUOROPHENYL)AMINO)-, (3S)-

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

865121

Created by admin on Sat Dec 16 18:50:34 GMT 2023 , Edited by admin on Sat Dec 16 18:50:34 GMT 2023

Code System Code Type Description

FDA UNII

AW8PEP3VZ3

Created by admin on Sat Dec 16 18:50:34 GMT 2023 , Edited by admin on Sat Dec 16 18:50:34 GMT 2023

PRIMARY

PUBCHEM

163203607

Created by admin on Sat Dec 16 18:50:34 GMT 2023 , Edited by admin on Sat Dec 16 18:50:34 GMT 2023

PRIMARY

CAS

2704617-96-7

Created by admin on Sat Dec 16 18:50:34 GMT 2023 , Edited by admin on Sat Dec 16 18:50:34 GMT 2023

PRIMARY

Related Record Type Details


					4AKO9FHJ4E

BROMODOMAIN-CONTAINING PROTEIN 9

TARGET->DEGRADER

Interaction Type:

PRECLINICAL

Amount:

Related Record Type Details


					AW8PEP3VZ3

CFT-8634

ACTIVE MOIETY

Comments:

CFT8634 is a novel Bifunctional Degradation Activating Compound Degrader, also known as a BiDAC™ degrader, of bromodomain-containing protein 9 (BRD9). CFT8634 is comprised of ligand binding moieties for BRD9 and the cereblon (CRBN) E3 ligase. CRBN facilitates E3 ligasecatalyzed ubiquitination of BRD9. Following polyubiquitination, BRD9 is then degraded by the cellular proteasome.

Amount: