2-PYRIDINEETHANAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H10N2
Molecular Weight	122.1677
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC1=CC=CC=N1

InChI

InChIKey=XPQIPUZPSLAZDV-UHFFFAOYSA-N

InChI=1S/C7H10N2/c8-5-4-7-3-1-2-6-9-7/h1-3,6H,4-5,8H2

HIDE SMILES / InChI

Molecular Formula	C7H10N2
Molecular Weight	122.1677
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14667234	Antagonist 2778		5.9 null [pIC50]

PubMed

Title	Date	PubMed
Regulation of interleukin-6, and macrophage colony-stimulating factor mRNA levels by histamine in stromal cell line (MC3T3-G2/PA6).	1998 May	9657254
H3 receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways.	2001 Feb	11219402
Effects of betahistine and of its metabolites on vestibular sensory organs.	2001 Jun	11677836
Formation, characterization, and reactivity of bis(mu-oxo)dinickel(III) complexes supported by a series of bis[2-(2-pyridyl)ethyl]amine ligands.	2001 Nov 14	11697960
Contractile response of horse deep dorsal penile vein to histamine.	2002 Apr	11979322
Oxo-transfer reaction from a bis(mu-oxo)dicopper(III) complex to sulfides.	2002 Feb 13	11829608
Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice.	2002 May	12095164
Excitatory effects of histamine on cerebellar interpositus nuclear cells of rats through H(2) receptors in vitro.	2002 Sep 6	12383956
Histamine-induced chloride secretion is mediated via H2-receptors in the pig proximal colon.	2003 Feb	12665126
Synthesis of 17beta-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines.	2003 Nov 17	14592477
Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro.	2003 Nov 6	14550905
Nickel(II) cyclidenes with appended ethylpyridine receptor centers as molecular tweezers for dicarboxylic acids.	2003 Oct 20	14552627
Biological evaluation of novel estrogen-platinum(II) hybrid molecules on uterine and ovarian cancers-molecular modeling studies.	2004 Dec 6	15501069
Bis(saccharinato-kappa N)zinc(II) complexes with N,N'-bidentate 2-aminomethylpyridine and 2-aminoethylpyridine.	2004 Jan	14712030
Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor.	2004 Jul	15206929
Dimetallic complexes of acyclic pyridine-armed ligands derived from 3,6-diformylpyridazine.	2004 Jul 21	15249952
Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity.	2004 Sep	15331534
Isatin-Schiff base copper(II) complexes and their influence on cellular viability.	2005 Jul	15878622
Silver(I) complexes of 2-(2-aminoethyl)pyridine: nitrate and perchlorate salts of bis[mu-2-(2-aminoethyl)pyridine-kappa(2)N:N']disilver(I).	2005 Jun	15930665
Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro.	2005 Nov	16143415
Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP.	2006 Oct 10	16920098
Pro-apoptotic activity of novel Isatin-Schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage.	2007 Apr 20	17327230
Dicopper(II) complexes of a new pyrazolate-containing Schiff-base macrocycle and related acyclic ligand.	2007 Jan 28	17213932
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.	2007 Mar 1	17174092
Ligand effects on Ni(II)-catalysed alkane-hydroxylation with m-CPBA.	2007 Mar 21	17339995
Synthesis of 17beta-estradiol-platinum(II) hybrid molecules showing cytotoxic activity on breast cancer cell lines.	2008 Apr 1	18356047
Metal-assisted in situ formation of a tridentate acetylacetone ligand for complexation of fac-Re(CO)3+ for radiopharmaceutical applications.	2008 Apr 7	18298058
Formation of {Cu2(III)(mu-O)2}2+ core due to dioxygen reactivity of a copper(I) complex supported by a new hybrid tridentate ligand: reaction with exogenous substrates.	2008 Aug	18729094
Bis{μ-2-[2-(2-pyrid-yl)ethyl-imino-meth-yl]phenolato}bis-[azido-zinc(II)].	2008 May 10	21202480
μ-Squarato-κO:O-bis-{[2-(2-amino-ethyl)pyridine-κN,N']aqua-nickel(II)} squarate 0.25-hydrate.	2008 Sep 27	21201075
2-[2-(2-Pyrid-yl)eth-yl]isoindolinium perchlorate.	2009 Aug 19	21577581
2-(2-Ammonio-ethyl)pyridinium hexa-chloridorhenate(IV).	2009 Feb 4	21582039

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:32:52 GMT 2023` Edited by `admin` on `Fri Dec 15 18:32:52 GMT 2023`
Record UNII	ATW1AH7OJ5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-PYRIDINEETHANAMINE

Systematic Name

English

2-(2-PYRIDINYL)ETHANAMINE

Systematic Name

English

2-(2-AMINOETHYL)PYRIDINE

Systematic Name

English

DEMETHYLBETAHISTINE

Common Name

English

.ALPHA.-(2-AMINOETHYL)PYRIDINE

Common Name

English

2-(2'-AMINOETHYL)PYRIDINE

Common Name

English

2-(2-PYRIDYL)ETHYLAMINE

Systematic Name

English

.ALPHA.-PYRIDYLETHYLAMINE

Systematic Name

English

2'-AMINOETHYL-2-PYRIDINE

Common Name

English

NSC-71989

Code

English

N-(2-(2-PYRIDINYL)ETHYL)AMINE

Systematic Name

English

PYRIDINE, 2-(2-AMINOETHYL)-

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

2-Pyridylethylamine