EMD-534085

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H31F3N4O2
Molecular Weight	476.5344
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCNC(=O)NC[C@H]1CC[C@H]2[C@@H](NC3=C(C=C(C=C3)C(F)(F)F)[C@H]2O1)C4=CC=CC=C4

InChI

InChIKey=MARIUIDCPUZLKZ-FUKQBSRTSA-N

InChI=1S/C25H31F3N4O2/c1-32(2)13-12-29-24(33)30-15-18-9-10-19-22(16-6-4-3-5-7-16)31-21-11-8-17(25(26,27)28)14-20(21)23(19)34-18/h3-8,11,14,18-19,22-23,31H,9-10,12-13,15H2,1-2H3,(H2,29,30,33)/t18-,19+,22+,23+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H31F3N4O2
Molecular Weight	476.5344
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Kinesin-like protein 1 12 Target ID: CHEMBL4581 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20149654	Inhibitor 8504		8.0 nM [IC50]

C_max

Value	Dose	Analyte	Population
92.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	2 mg/m² single, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
144.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	4 mg/m² single, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
202.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	6 mg/m² single, intravenous dose: 6 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
325.2 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	9 mg/m² single, intravenous dose: 9 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
357.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	14 mg/m² single, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
680.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	21 mg/m² single, intravenous dose: 21 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
827.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	32 mg/m² single, intravenous dose: 32 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1817 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	48 mg/m² single, intravenous dose: 48 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1563.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	72 mg/m² single, intravenous dose: 72 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4757.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	108 mg/m² single, intravenous dose: 108 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4275.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	135 mg/m² single, intravenous dose: 135 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
101.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	2 mg/m² 1 times / 3 weeks multiple, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
252.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	4 mg/m² 1 times / 3 weeks multiple, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
260.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	6 mg/m² 1 times / 3 weeks multiple, intravenous dose: 6 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
352.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	9 mg/m² 1 times / 3 weeks multiple, intravenous dose: 9 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
431 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	14 mg/m² 1 times / 3 weeks multiple, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
430 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	21 mg/m² 1 times / 3 weeks multiple, intravenous dose: 21 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
637.1 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	32 mg/m² 1 times / 3 weeks multiple, intravenous dose: 32 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1853.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	48 mg/m² 1 times / 3 weeks multiple, intravenous dose: 48 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2759.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	72 mg/m² 1 times / 3 weeks multiple, intravenous dose: 72 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4895.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	108 mg/m² 1 times / 3 weeks multiple, intravenous dose: 108 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
5897.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	135 mg/m² 1 times / 3 weeks multiple, intravenous dose: 135 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
1345 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	2 mg/m² single, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2804 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	4 mg/m² single, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3134 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	6 mg/m² single, intravenous dose: 6 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4495 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	9 mg/m² single, intravenous dose: 9 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
6379 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	14 mg/m² single, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
8883 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	21 mg/m² single, intravenous dose: 21 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11288 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	32 mg/m² single, intravenous dose: 32 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
27695 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	48 mg/m² single, intravenous dose: 48 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
17659 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	72 mg/m² single, intravenous dose: 72 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
80526 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	108 mg/m² single, intravenous dose: 108 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
85223 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	135 mg/m² single, intravenous dose: 135 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1262 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	2 mg/m² 1 times / 3 weeks multiple, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2765 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	4 mg/m² 1 times / 3 weeks multiple, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3429 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	6 mg/m² 1 times / 3 weeks multiple, intravenous dose: 6 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4972 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	9 mg/m² 1 times / 3 weeks multiple, intravenous dose: 9 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
5078 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	14 mg/m² 1 times / 3 weeks multiple, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
6514 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	21 mg/m² 1 times / 3 weeks multiple, intravenous dose: 21 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
11508 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	32 mg/m² 1 times / 3 weeks multiple, intravenous dose: 32 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
29408 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	48 mg/m² 1 times / 3 weeks multiple, intravenous dose: 48 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
42140 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	72 mg/m² 1 times / 3 weeks multiple, intravenous dose: 72 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
80700 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	108 mg/m² 1 times / 3 weeks multiple, intravenous dose: 108 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
84899 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	135 mg/m² 1 times / 3 weeks multiple, intravenous dose: 135 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
47.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	2 mg/m² single, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
61.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	4 mg/m² single, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
57.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	6 mg/m² single, intravenous dose: 6 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
58.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	9 mg/m² single, intravenous dose: 9 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
48.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	14 mg/m² single, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
46.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	21 mg/m² single, intravenous dose: 21 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
60.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	32 mg/m² single, intravenous dose: 32 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
48.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	48 mg/m² single, intravenous dose: 48 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
43.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	72 mg/m² single, intravenous dose: 72 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
47.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	108 mg/m² single, intravenous dose: 108 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
50.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	135 mg/m² single, intravenous dose: 135 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
43.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	2 mg/m² 1 times / 3 weeks multiple, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
52.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	4 mg/m² 1 times / 3 weeks multiple, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
57.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	6 mg/m² 1 times / 3 weeks multiple, intravenous dose: 6 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
51.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	9 mg/m² 1 times / 3 weeks multiple, intravenous dose: 9 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
51.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	14 mg/m² 1 times / 3 weeks multiple, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
57.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	21 mg/m² 1 times / 3 weeks multiple, intravenous dose: 21 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
53.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	32 mg/m² 1 times / 3 weeks multiple, intravenous dose: 32 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
39.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	48 mg/m² 1 times / 3 weeks multiple, intravenous dose: 48 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
42 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	72 mg/m² 1 times / 3 weeks multiple, intravenous dose: 72 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
43.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	108 mg/m² 1 times / 3 weeks multiple, intravenous dose: 108 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
40.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24077982/	135 mg/m² 1 times / 3 weeks multiple, intravenous dose: 135 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	EMD-534085 plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.	2008-05-01	18451153

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:18:05 GMT 2025` Edited by `admin` on `Mon Mar 31 23:18:05 GMT 2025`
Record UNII	AL67QX8036
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EMD-534085

Common Name

English

(-)-EMD-534085

Preferred Name

English

UREA, N-(2-(DIMETHYLAMINO)ETHYL)-N'-(((2R,4AS,5R,10BS)-3,4,4A,5,6,10B-HEXAHYDRO-5-PHENYL-9-(TRIFLUOROMETHYL)-2H-PYRANO(3,2-C)QUINOLIN-2-YL)METHYL)-

Systematic Name

English

1-(2-(DIMETHYLAMINO)ETHYL)-3-(((2R,4AS,5R,10BS)-5-PHENYL-9-(TRIFLUOROMETHYL)-3,4,4A,5,6,10B-HEXAHYDRO-2H-PYRANO(3,2-C)QUINOLIN-2-YL)METHYL)UREA

Systematic Name

English

Code System Code Type Description

SMS_ID

300000042440