HALOPROGIN

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H4Cl3IO
Molecular Weight	361.391
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC(Cl)=C(Cl)C=C1OCC#CI

InChI

InChIKey=CTETYYAZBPJBHE-UHFFFAOYSA-N

InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2

HIDE SMILES / InChI

Molecular Formula	C9H4Cl3IO
Molecular Weight	361.391
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf

Haloprogin is an active synthetic antifungal and antimonilial agent that was effective in the treatment of superficial fungal and monilial infections of the skin. Because of these two basic therapeutic effects, haloprogin was especially useful in the treatment of infections when the identity of the specific causative organism had not been established or is being determined. Studies in-vitro demonstrated antifungal, antimonilial and antibacterial activity. It was shown to demonstrate marked in-vitro activity against Staphylococcus and Streptococcus. Haloprogin is no longer available in the US.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Tinea pedis 28 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf	Curative	Approved 8429	HALOTEX Approved Use Unknown
Tinea cruris 11 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf	Curative	Approved 8429	HALOTEX Approved Use Unknown
Tinea corporis 19 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf	Curative	Approved 8429	HALOTEX Approved Use Unknown
Tinea manuum 3 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf	Curative	Approved 8429	HALOTEX Approved Use Unknown
Tinea versicolor 3 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf	Curative	Approved 8429	HALOTEX Approved Use Unknown
Monilial infections of the skin caused by Candida albicans 1 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2274405&blobtype=pdf	Curative	Approved 8429	HALOTEX Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY571490	https://www.001chemical.com/chem/777-11-7
AHH Chemical co.,ltd	MR-1002868	http://www.ahhchemical.com/product/MR-1002868.html
AK Scientific, Inc. (AKSCI)	Z3201	http://www.aksci.com/item_detail.php?cat=Z3201
Achemtek	0102-014329	http://www.achemtek.com/777-11-7
Ambinter	Amb13889621	http://www.ambinter.com/reference/13889621
BLD Pharm	BD132631	http://www.bldpharm.com/products/777-11-7.html
BioChemPartner	BCP20218	http://www.biochempartner.com/777-11-7-BCP20218
ChemMol	49428833	http://www.chemmol.com/chemmol/49428833.html
ChemMol	99142520	http://www.chemmol.com/chemmol/99142520.html
Clearsynth	CS-T-78199	https://www.clearsynth.com/en/CST78199.html
Molcore	MC571490	https://www.molcore.com/product/777-11-7
OChem	11878	http://www.ocheminc.com/index.php?act=psearch&pid=777H117
Smolecule	S529749	http://www.smolecule.com/products/s529749
Smolecule	S793306	https://www.smolecule.com/products/s793306
THE BioTek	bt-269298	https://www.thebiotek.com/product/inhibitors/bt-269298
eNovation Chemicals	D674457	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674457

PubMed

Title	Date	PubMed
Haloprogin: a topical antifungal agent.	1970 May	5422306
Haloprogin: mode of action studies in Candida albicans.	1974 Sep	4608935
In vitro activity of ME1401, a new antifungal agent.	1986 Nov	3800346
Synthesis and microbiological activity of some novel 5- or 6-methyl-2-(2,4-disubstituted phenyl) benzoxazole derivatives.	1998 May 30	9679283
Synthesis and microbiological activity of some N-(o-hydroxyphenyl)benzamides and phenylacetamides as the possible metabolites of antimicrobial active benzoxazoles: part II.	2000 Jun-Jul	11204748
(E)-2-{(2-Hydroxy-naphthalen-1-yl)methyl-ene}hydrazinecarboxamide.	2009 Apr 25	21583924
1-(5-Carboxy-pent-yl)-2,3,3-trimethyl-3H-indol-1-ium bromide monohydrate.	2009 Dec 16	21580058
2,4-Dichloro-1-[1-(2,4-dichloro-benz-yl-oxy)eth-yl]benzene.	2009 Dec 16	21580052
Gabapentin-lactum-chloranilic acid (1/1).	2009 Dec 16	21580051
11-[3-(Dimethyl-amino)prop-yl]-6,11-dihydro-dibenzo[b,e]thiepin-11-ol.	2009 Dec 16	21580050
6,11-Dihydro-dibenz[b,e]oxepin-11-one.	2009 Dec 16	21580048
N-(3,4-Dichloro-phen-yl)-3-oxo-butanamide.	2009 Dec 4	21580160
(E)-2-[(2-Hydr-oxy-5-nitro-phen-yl)iminiometh-yl]phenolate.	2009 Feb 11	21582157
(E)-2-[(2-Hydr-oxy-5-nitro-phen-yl)iminiometh-yl]-4-nitro-phenolate.	2009 Jan 14	21581902
3-(2,6-Dioxopiperidin-3-yl)-3-aza-bicyclo-[3.2.0]heptane-2,4-dione.	2009 Jan 28	21581989
3-(2-Chloro-ethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one.	2009 Jul 25	21583662
A second polymorph of (2E)-1-(4-fluoro-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)prop-2-en-1-one.	2009 Jul 25	21583642
Environmental stresses inhibit splicing in the aquatic fungus Blastocladiella emersonii.	2009 Oct 29	19874600
7-(4-Bromo-phen-yl)-9-phenyl-7H-pyrrolo[3,2-e]tetra-zolo[1,5-c]pyrimidine.	2010 Feb 10	21580341
6-{[(Benz-yloxy)carbon-yl]-oxy}-2-methyl-hexa-hydro-pyrano[3,2-d][1,3]dioxin-7,8-diyl bis-(chloro-acetate).	2010 Feb 10	21580340
7-(4-Chloro-phen-yl)-9-phenyl-7H-pyrrolo[3,2-e]tetra-zolo[1,5-c]pyrimidine.	2010 Feb 13	21580361
Desipramine hydro-chloride: a non-merohedrally twinned structure.	2010 Feb 20	21580421
(E)-2-Acetyl-4-[(3-methyl-phenyl-)diazen-yl]phenol: an X-ray and DFT study.	2010 Feb 6	21580328
1-(1,3-Benzodioxol-5-yl)ethanone.	2010 Jan 16	21579805
Trimipraminium maleate.	2010 Jan 16	21579790
N,N'-Bis-[(E)-2-fluoro-benzyl-idene]-1-(2-fluoro-phen-yl)methane-diamine.	2010 Jan 23	21579838
(2E)-1-(2-Bromo-phen-yl)-3-(4-meth-oxy-phen-yl)prop-2-en-1-one.	2010 Jun 16	21587888
Simultaneous spectrophotometric estimation of haloperidol and trihexyphenidyl in tablets.	2010 Mar	20838539
4-Phenyl-sulfon-yl-2-(p-tolyl-sulfon-yl)-1H,8H-pyrrolo-[2,3-b]indole.	2010 Oct 9	21588961

Sample Use Guides

In Vivo Use Guide

1% cream or solution applied liberally to the affected area twice daily

Route of Administration: Topical

In Vitro Use Guide

The in vitro fungistatic concentrations were determined by a serial dilution method using Sabouraud's liquid medium. The concentration of drug tested ranged from 0.19 to 100 ug/ml. All tubes were inoculated with approximately 10(5) viable macrospores obtained by washing the surface of a 14-day slant culture of the test dermatophyte with Sabouraud's liquid medium and diluting to the desired concentration. The inoculated assay tubes were incubated at room temperature (28 Celsius) for 7 days and examined for visible growth.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:05:26 GMT 2023` Edited by `admin` on `Sat Dec 16 16:05:26 GMT 2023`
Record UNII	AIU7053OWL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HALOPROGIN

Official Name

English

M-1028 (MEIJI)

Code

English

HALOPROGIN [ORANGE BOOK]

Common Name

English

Haloprogin [WHO-DD]

Common Name

English

M-1028

Code

English

HALOPROGIN [MART.]

Common Name

English

3-Iodo-2-propynyl 2,4,5-trichlorophenyl ether

Systematic Name

English

haloprogin [INN]

Common Name

English

HALOPROGIN [JAN]

Common Name

English

HALOPROGIN [MI]

Common Name

English

HALOTEX

Brand Name

English

HALOPROGIN [USAN]

Common Name

English

BENZENE, 1,2,4-TRICHLORO-5-((3-IODO-2-PROPYNYL)OXY)-

Systematic Name

English

HALOPROGIN [VANDF]

Common Name

English

NSC-100071

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C514