Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.4275 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC3=C4C(C[C@H]5N(CC=C(C)C)CC[C@@]14[C@@]5(O)CCC2=O)=CC=C3O
InChI
InChIKey=OHKCLOQPSLQCQR-MBPVOVBZSA-N
InChI=1S/C21H25NO4/c1-12(2)6-9-22-10-8-20-17-13-3-4-14(23)18(17)26-19(20)15(24)5-7-21(20,25)16(22)11-13/h3-4,6,16,19,23,25H,5,7-11H2,1-2H3/t16-,19+,20+,21-/m1/s1
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.4275 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Nalmexone is an opioid partial agonist or mixed agonist-antagonist with both analgesic and narcotic antagonist properties. In preclinical models parenteral nalmexone was a moderately active antagonist and therefore might have low abuse potential. At the same time, early work in man indicated analgesic
activity in doses above 20 mg.
Approval Year
Sample Use Guides
Doses of 5 mg and 10 mg of morphine were
compared with 15 mg and 30 mg of nalmexone in the first study and with 40 mg and 60 mg of nalmexone in the second one. Each patient was given a "round" of 4 medications, a low and high dose of morphine with a low and high dose of nalmexone, to establish and compare doseeffect curves of the 2 drugs. The medications were prepared in identical ampules and administered intramuscularly under random, double-blind conditions.
Route of Administration:
Intramuscular
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:48:59 UTC 2023
by
admin
on
Fri Dec 15 15:48:59 UTC 2023
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| Record UNII |
AIB278UKIG
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Name | Type | Language | ||
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Official Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C681
Created by
admin on Fri Dec 15 15:48:59 UTC 2023 , Edited by admin on Fri Dec 15 15:48:59 UTC 2023
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| Code System | Code | Type | Description | ||
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AIB278UKIG
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Nalmexone
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C83978
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SUB09140MIG
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2443
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100000084461
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C005300
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CHEMBL2111160
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16676-26-9
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5360516
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DTXSID80168172
Created by
admin on Fri Dec 15 15:48:59 UTC 2023 , Edited by admin on Fri Dec 15 15:48:59 UTC 2023
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PRIMARY |
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
