Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H20N4O2S |
| Molecular Weight | 392.474 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=S(=O)(C1=NNC2=C1C=C(C=C2)N3CCNCC3)C4=CC=CC5=CC=CC=C45
InChI
InChIKey=FYOVZCDHYOEKDE-UHFFFAOYSA-N
InChI=1S/C21H20N4O2S/c26-28(27,20-7-3-5-15-4-1-2-6-17(15)20)21-18-14-16(8-9-19(18)23-24-21)25-12-10-22-11-13-25/h1-9,14,22H,10-13H2,(H,23,24)
| Molecular Formula | C21H20N4O2S |
| Molecular Weight | 392.474 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:30:39 GMT 2025
by
admin
on
Tue Apr 01 16:30:39 GMT 2025
|
| Record UNII |
AF9MF92XFM
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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AF9MF92XFM
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
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PRIMARY | |||
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3-(1-NAPHTHALENYLSULFONYL)-5-(1-PIPERAZINYL)-1H-INDAZOLE
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
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PRIMARY | HY-14334 CAS:744218-85-7 (Synonyms SAM-315) | ||
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300000041395
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
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PRIMARY | |||
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744218-85-7
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
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PRIMARY | |||
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10430623
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
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PRIMARY | |||
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WAY-255315
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
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PRIMARY | Primary: To assess the safety and tolerability of ascending multiple oral doses of SAM-315, an investigational drug, in healthy young adult and elderly subjects.Secondary: To assess the Pharmacokinetic and Pharmacodynamic profiles of multiple oral doses of SAM-315 in healthy young adult and elderly subjects. | ||
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WAY-255315
Created by
admin on Tue Apr 01 16:30:39 GMT 2025 , Edited by admin on Tue Apr 01 16:30:39 GMT 2025
|
PRIMARY | Primary: To assess the safety and tolerability of ascending multiple oral doses of SAM-315, an investigational drug, in healthy young adult and elderly subjects.Secondary: To assess the Pharmacokinetic and Pharmacodynamic profiles of multiple oral doses of SAM-315 in healthy young adult and elderly subjects. |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described. Ki = 1.1 NM, IC50 = 13 nM
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