TACATRESGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 12:22:12 GMT 2025` Edited by `admin` on `Wed Apr 02 12:22:12 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	t cells
Record UNII	AD2HJ5CF2N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TACATRESGENE AUTOLEUCEL

Official Name

English

AUTOLOGOUS T CELLS OBTAINED FROM THE PERIPHERAL BLOOD OF PATIENTS, COLLECTED BY LEUKAPHERESIS, MODIFIED BY CRISPR/CAS9 (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 9) MEDIATED GENE EDITING CONSISTING OF TWO GUIDE R

Preferred Name

English

tacatresgene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

AD2HJ5CF2N

Created by admin on Wed Apr 02 12:22:12 GMT 2025 , Edited by admin on Wed Apr 02 12:22:12 GMT 2025

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SMS_ID

300000054852

Created by admin on Wed Apr 02 12:22:12 GMT 2025 , Edited by admin on Wed Apr 02 12:22:12 GMT 2025

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NCI_THESAURUS

C203190

Created by admin on Wed Apr 02 12:22:12 GMT 2025 , Edited by admin on Wed Apr 02 12:22:12 GMT 2025

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INN

11534

Created by admin on Wed Apr 02 12:22:12 GMT 2025 , Edited by admin on Wed Apr 02 12:22:12 GMT 2025

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Related Record Type Details


					AD2HJ5CF2N

TACATRESGENE AUTOLEUCEL

ACTIVE MOIETY

Comments:

Cell-based gene therapy (antineoplastic)

Amount:

Agent Modifications

Modification Process	Modification Role	Fragment Name	Fragment ID
ELECTROPORATION	CRISPR/CAS9	Tacatresgene autoleucel Guide RNA (gRNA) sequences (TRAC-1)	AC4JY4Q9AK
ELECTROPORATION	CRISPR/CAS9	TACATRESGENE AUTOLEUCEL GUIDE RNA (GRNA) SEQUENCES (TRBC-1)	3KQV6T97QD
CULTURE	ACTIVATOR	HUMAN IL-15	HRJ300HC9W
CULTURED	ACTIVATOR	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
ELECTROPORATION	TRANSFECTION	TACATRESGENE AUTOLEUCEL PATIENT-DERIVED TUMOUR-SPECIFIC NEOEPITOPE T CELL RECEPTOR (NEO-TCR) GENE CASSETTE PLASMID	2PU2KKM5DV

Name	Property Type	Referenced Substance
ANTIGEN EXPRESSED	BIOLOGICAL	`8OYI5QX0HL` T-CELL SURFACE GLYCOPROTEIN CD4

ANTIGEN EXPRESSED	BIOLOGICAL	`2946IE3VYD` CD8