U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:49:58 UTC 2023
Edited
by admin
on Sat Dec 16 18:49:58 UTC 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name T CELLS
Record UNII
AD2HJ5CF2N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TACATRESGENE AUTOLEUCEL
INN  
Official Name English
tacatresgene autoleucel [INN]
Common Name English
AUTOLOGOUS T CELLS OBTAINED FROM THE PERIPHERAL BLOOD OF PATIENTS, COLLECTED BY LEUKAPHERESIS, MODIFIED BY CRISPR/CAS9 (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 9) MEDIATED GENE EDITING CONSISTING OF TWO GUIDE R
Common Name English
Code System Code Type Description
FDA UNII
AD2HJ5CF2N
Created by admin on Sat Dec 16 18:49:58 UTC 2023 , Edited by admin on Sat Dec 16 18:49:58 UTC 2023
PRIMARY
INN
11534
Created by admin on Sat Dec 16 18:49:58 UTC 2023 , Edited by admin on Sat Dec 16 18:49:58 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
Cell-based gene therapy (antineoplastic)

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
ELECTROPORATION CRISPR/CAS9 TACATRESGENE AUTOLEUCEL GUIDE RNA (GRNA) SEQUENCES (TRAC-1) AC4JY4Q9AK
ELECTROPORATION CRISPR/CAS9 TACATRESGENE AUTOLEUCEL GUIDE RNA (GRNA) SEQUENCES (TRBC-1) 3KQV6T97QD
CULTURE ACTIVATOR HUMAN IL-15 HRJ300HC9W
CULTURED ACTIVATOR INTERLEUKIN-7 HUMAN RECOMBINANT 418XB47Y71
ELECTROPORATION TRANSFECTION TACATRESGENE AUTOLEUCEL PATIENT-DERIVED TUMOUR-SPECIFIC NEOEPITOPE T CELL RECEPTOR (NEO-TCR) GENE CASSETTE PLASMID 2PU2KKM5DV
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL