Opelkibart elmanitin

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:56:28 GMT 2025` Edited by `admin` on `Wed Apr 02 11:56:28 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	AB5KZ6L2SU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Opelkibart elmanitin

Official Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens KIT (KIT proto-oncogene receptor tyrosine kinase, c-kit, SCFR, CD117)], Homo sapiens monoclonal antibody, conjugated, via a noncleavable linker, at the sulfur atoms of cysteine residues 271 and 271'' to a synth

Preferred Name

English

opelkibart elmanitin [INN]

Common Name

English

Code System Code Type Description

FDA UNII

AB5KZ6L2SU

Created by admin on Wed Apr 02 11:56:28 GMT 2025 , Edited by admin on Wed Apr 02 11:56:28 GMT 2025

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INN

12811

Created by admin on Wed Apr 02 11:56:28 GMT 2025 , Edited by admin on Wed Apr 02 11:56:28 GMT 2025

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NCI_THESAURUS

C204148

Created by admin on Wed Apr 02 11:56:28 GMT 2025 , Edited by admin on Wed Apr 02 11:56:28 GMT 2025

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SMS_ID

300000055868

Created by admin on Wed Apr 02 11:56:28 GMT 2025 , Edited by admin on Wed Apr 02 11:56:28 GMT 2025

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CAS

2771389-45-6

Created by admin on Wed Apr 02 11:56:28 GMT 2025 , Edited by admin on Wed Apr 02 11:56:28 GMT 2025

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From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_373	2_431
2_267	2_327
2_226	4_214
2_150	2_206
2_22	2_96
1_373	1_431
1_267	1_327
1_235	2_235
1_232	2_232
1_226	3_214
1_150	1_206
1_22	1_96

Glycosylation Link Type	Site
N	1_303
N	2_303

Related Record Type Details


					AB5KZ6L2SU

Opelkibart elmanitin

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_453] [2_453]	SITE_SPECIFIC		Amount:	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_271] [2_271]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	977afde9 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL