Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H26N8 |
| Molecular Weight | 426.5168 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C(CCC1=NC2=C(N1)C=CC(=C2)C3=NCCN3)CC4=NC5=CC=C(C=C5N4)C6=NCCN6
InChI
InChIKey=HSOKEDVIVDSCPU-UHFFFAOYSA-N
InChI=1S/C24H26N8/c1(3-21-29-17-7-5-15(13-19(17)31-21)23-25-9-10-26-23)2-4-22-30-18-8-6-16(14-20(18)32-22)24-27-11-12-28-24/h5-8,13-14H,1-4,9-12H2,(H,25,26)(H,27,28)(H,29,31)(H,30,32)
| Molecular Formula | C24H26N8 |
| Molecular Weight | 426.5168 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia. | 1993 Aug |
|
| Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells. | 1994 Sep |
|
| New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. | 1995 Nov 24 |
|
| Pentamidine is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 receptors. | 1999 Jun 21 |
Sample Use Guides
Rats: 1,4-BIS(5-(2-IMIDAZOLINYL)-2-BENZIMIDAZOLYL)BUTANE showed excellent activity down to a dose of 2.5 mg/kg/day and produced a significant reduction, compared with the saline control group, in the number of cysts per gram of lung tissue at a dose of 1 mg/kg/day. A compound showed no overt toxicity when administered at 15mg/kg/day for 14 days.
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:04:50 GMT 2023
by
admin
on
Sat Dec 16 08:04:50 GMT 2023
|
| Record UNII |
A9K12S2G4K
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID50933394
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A9K12S2G4K
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148344-24-5
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
