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Details

Stereochemistry ACHIRAL
Molecular Formula C13H14O6
Molecular Weight 266.2467
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of BAXITOZINE

SMILES

COC1=CC(=CC(OC)=C1OC)C(=O)\C=C\C(O)=O

InChI

InChIKey=PVCWLTQMJSUKGZ-SNAWJCMRSA-N
InChI=1S/C13H14O6/c1-17-10-6-8(9(14)4-5-12(15)16)7-11(18-2)13(10)19-3/h4-7H,1-3H3,(H,15,16)/b5-4+

HIDE SMILES / InChI

Molecular Formula C13H14O6
Molecular Weight 266.2467
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Baxitozine is a Histamine H2 receptor antagonist. It has a cytoprotective, antisecretory and antiulcer properties. In situ, baxitozine inhibited acid secretion stimulated by histamine or pentagastrin but was inactive against carbachol. It also had antiulcer activity against stress ulcers (restraint plus cold). It had marked gastric cytoprotective activity in rats against the necrotizing effects of ethanol. This cytoprotective activity was not significantly affected by indomethacin pre-treatment. Baxitozine has been in phase II clinical trials for the treatment of gastric ulcer. However, this research has been discontinued.

Approval Year

Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Rat data
Single doses 2.5, 5 or 10 mg/kg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:03:22 GMT 2023
Edited
by admin
on Fri Dec 15 16:03:22 GMT 2023
Record UNII
A89J34472U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BAXITOZINE
INN  
INN  
Official Name English
(E)-3-(3,4,5-TRIMETHOXYBENZOYL)ACRYLIC ACID
Systematic Name English
baxitozine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29698
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2104000
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
EPA CompTox
DTXSID701009379
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
CAS
84386-11-8
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
SMS_ID
100000086109
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
INN
6210
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
PUBCHEM
6366494
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
EVMPD
SUB05671MIG
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
FDA UNII
A89J34472U
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
NCI_THESAURUS
C73191
Created by admin on Fri Dec 15 16:03:22 GMT 2023 , Edited by admin on Fri Dec 15 16:03:22 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY