Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H26ClF2N5O2.C4H11N |
| Molecular Weight | 563.082 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)N.C[C@@H]1C[C@@](CC2=NC(NC3=NNC(C)=C3)=CC=C2F)(CCN1CC4=CC=CC(Cl)=C4F)C(O)=O
InChI
InChIKey=NDMQCGPEDPLXAO-GYKIMTNYSA-N
InChI=1S/C24H26ClF2N5O2.C4H11N/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27;1-4(2,3)5/h3-7,10,15H,8-9,11-13H2,1-2H3,(H,33,34)(H2,28,29,30,31);5H2,1-3H3/t15-,24-;/m1./s1
| Molecular Formula | C4H11N |
| Molecular Weight | 73.1368 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C24H26ClF2N5O2 |
| Molecular Weight | 489.945 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
17900 μg/L |
50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
17900 μg/L |
25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
3350 μg/L |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
128000 μg × h/L |
50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
128000 μg × h/L |
25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
20800 μg × h/L |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
21 h |
25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
LY3295668 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 00:20:55 GMT 2025
by
admin
on
Wed Apr 02 00:20:55 GMT 2025
|
| Record UNII |
A7TCD5V515
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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Code | English | ||
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Preferred Name | English | ||
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Systematic Name | English |
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146597589
Created by
admin on Wed Apr 02 00:20:55 GMT 2025 , Edited by admin on Wed Apr 02 00:20:55 GMT 2025
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A7TCD5V515
Created by
admin on Wed Apr 02 00:20:55 GMT 2025 , Edited by admin on Wed Apr 02 00:20:55 GMT 2025
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C165238
Created by
admin on Wed Apr 02 00:20:55 GMT 2025 , Edited by admin on Wed Apr 02 00:20:55 GMT 2025
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PRIMARY |
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|---|---|---|---|---|
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|---|---|---|---|---|
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ACTIVE MOIETY |
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