Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C29H55N5O18 |
Molecular Weight | 761.7697 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 23 / 23 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]4(O[C@@H]1[C@@H](CO)O[C@@H](O[C@]2([H])[C@@H](O)[C@H](N)C[C@H](N)[C@@]2([H])O[C@H]3O[C@H](CO)[C@@H](O)C[C@H]3N)[C@@H]1O)O[C@@H](CN)[C@@]([H])(O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@H](O)[C@H]4N
InChI
InChIKey=DBLVDAUGBTYDFR-SWMBIRFSSA-N
InChI=1S/C29H55N5O18/c30-3-11-23(51-28-20(43)19(42)17(40)13(5-36)47-28)18(41)15(34)27(45-11)50-24-14(6-37)48-29(21(24)44)52-25-16(39)7(31)1-8(32)22(25)49-26-9(33)2-10(38)12(4-35)46-26/h7-29,35-44H,1-6,30-34H2/t7-,8+,9-,10+,11+,12-,13-,14-,15-,16+,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+/m1/s1
Molecular Formula | C29H55N5O18 |
Molecular Weight | 761.7697 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 23 / 23 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Lividomycin is the antibacterial agent produced by Streptomyces lividus. It is aminoglycoside antibiotic. Lividomycin binds to bacterial ribosomes and inhibits protein synthesis. In vitro development of resistance to lividomycin in P. aeruginosa and M. tuberculosis was much slower than that to kanamycin, but was comparable in Staphylococcus aureus. Lividomycin showed a positive protecting effect for the experimental infections in mice with several bacteria such as S. aureus, P. aeruginosa, Klebsiella pneumoniae and Escherichia coli. It was fairly effective for the experimental infection with the kanamycin-resistant strains of E. coli and P. aeruginosa producing the kanamycin-phosphorylating enzyme.
Approval Year
PubMed
Title | Date | PubMed |
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[Antituberculous action of a new antibiotic, Lividomycin. Effect on experimental tuberculosis of mice and cross resistance with other antituberculous agents]. | 1970 Aug |
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Studies on new antibiotic lividomycins. V. In vitro and in vivo antimicrobial activity of lividomycin A. | 1972 Feb |
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Chemical conversion of lividomycin A into lividomycin B. | 1972 Feb |
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A preliminary trial of lividomycin in patients with pulmonary tuberculosis. | 1972 Mar |
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Screening for new compounds with antiherpes activity. | 1984 Oct |
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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. | 2005 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:33:15 GMT 2023
by
admin
on
Sat Dec 16 16:33:15 GMT 2023
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Record UNII |
A606AJ494W
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Record Status |
Validated (UNII)
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Record Version |
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A606AJ494W
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Lividomycin
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CHEMBL389029
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Related Record | Type | Details | ||
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ACTIVE MOIETY |