Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H20O10 |
| Molecular Weight | 312.2705 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C=O
InChI
InChIKey=BYZQBCIYLALLPA-NOPGXMAYSA-N
InChI=1S/C11H20O10/c12-1-4(15)7(16)5(2-13)20-11-10(19)9(18)8(17)6(3-14)21-11/h1,4-11,13-19H,2-3H2/t4-,5+,6+,7+,8-,9-,10+,11+/m0/s1
| Molecular Formula | C11H20O10 |
| Molecular Weight | 312.2705 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Gaxilose is a synthetic disaccharide that is hydrolyzed in the intestine by the lactase enzyme. Gaxilose is used to diagnose hypolactasia via presence of D-xylose after cleavage by lactase. The Spanish company VenterPharma was issued with marketing authorisation by the Spanish and German regulatory agencies for LacTEST. Diagnosis drug LacTEST® represents a noninvasive method based on oral administration of 4-galactosil-xilose (4-O-β-D galactopiranosil-D-xilose) whose INN is Gaxilose, for hypolactasia diagnosis. This synthetic disaccharide, a substrate of intestinal lactase is hydrolyzed and the result is 2 physiological products: galactose and xylose. Galactose is converted into glucose in the liver and xylose is absorbed from a passive way and partially metabolized endogenously (50%). The rest appears in blood and it is excreted finally through urine. The amount of xylose in urine is proportional to the activity of intestinal lactase. This represents a direct measure of hypo or normo lactasia.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Analytical Validation of a New Enzymatic and Automatable Method for d-Xylose Measurement in Human Urine Samples. | 2017 |
|
| Improvement and validation of d-xylose determination in urine and serum as a new tool for the noninvasive evaluation of lactase activity in humans. | 2014-11 |
|
| Phase I and phase IB clinical trials for the noninvasive evaluation of intestinal lactase with 4-galactosylxylose (gaxilose). | 2013-07 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23328304
In the randomized, dose-finding, phase I study, urine and serum pharmacokinetics of D-xylose were determined after oral administration of 6 ascending doses of gaxilose (and placebo) to 12 healthy adult volunteers. Gaxilose administration showed a progressive, dose-dependent increase in D-xylose in urine and serum. An optimal gaxilose dose of 0.45 g and urine collection periods of 4 and 5 hours were selected for further studies.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:42:50 GMT 2025
by
admin
on
Mon Mar 31 19:42:50 GMT 2025
|
| Record UNII |
A571S2B3JE
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
100000160447
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
3082054
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
C174601
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
A571S2B3JE
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
DB12767
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
14087-31-1
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
9366
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
SUB172203
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
148937
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
DTXSID60161484
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
PRIMARY | |||
|
159702-00-8
Created by
admin on Mon Mar 31 19:42:50 GMT 2025 , Edited by admin on Mon Mar 31 19:42:50 GMT 2025
|
ALTERNATIVE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET->LIGAND |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|