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Details

Stereochemistry ACHIRAL
Molecular Formula C6H14O3
Molecular Weight 134.1736
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIETHYLENE GLYCOL MONOETHYL ETHER

SMILES

CCOCCOCCO

InChI

InChIKey=XXJWXESWEXIICW-UHFFFAOYSA-N
InChI=1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3

HIDE SMILES / InChI
Molecular Formula C6H14O3
Molecular Weight 134.1736
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Diethylene glycol monoethyl ether (under brand name Transcutol) is used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Transcutol is safe for use and has low irritancy inferred by numerous toxicological studies and precedence of use in approved topical medicines.

Approval Year

1955
124
PubMed

PubMed

TitleDatePubMed
Study of in vitro drug release and percutaneous absorption of fluconazole from topical dosage forms.
2010-06
Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil.
2009-10-01
Homogeneous, surfactant-free gold nanoparticles encapsulated by polythiophene analogues.
2009-04-21
Airborne concentrations of volatile organic compounds, formaldehyde and ammonia in Finnish office buildings with suspected indoor air problems.
2009-03
The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides.
2008-03-20
Control of transdermal permeation of hydrocortisone acetate from hydrophilic and lipophilic formulations.
2008
Inhibition of hyaluronan export reduces collagen degradation in interleukin-1 treated cartilage.
2008
A GC/MS study of the drying of ballpoint pen ink on paper.
2007-05-24
In vitro and in vivo stability of caffeic acid phenethyl ester, a bioactive compound of propolis.
2007-05-02
An evaluation of the allelopathic potential of selected perennial groundcovers: foliar volatiles of catmint (Nepeta x faassenii) inhibit seedling growth.
2006-08
Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids.
2005-03-28
Structure elucidation, synthesis, and contact allergenic activity of a major hydroperoxide formed at autoxidation of the ethoxylated surfactant C12E5.
2003-05
Enhanced skin permeation of a new capsaicin derivative (DA-5018) from a binary vehicle system composed of isopropyl myristate and ethoxydiglycol.
2001-06
Patents

Patents

05041455
2
05264444
1
05773452
1
06150522
1
08148380
2
JP2001158709A
1
JP2002530505A
2
JP2002537317A
97
JP2003026967A
1
JP2003534249A
12
JP2007503428A
35
JP2008050378A
1
JP2008163321A
1
JP2011194012A
1
JP2011513296A
1
JP2011528336A
1
JP4690334B2
2
JP5374811B2
1
JPH0485374A
1
JPH06122615A
2
JPH0625578A
1
JPH07165539A
1
JPH07288029A
1
JPH0762288A
1
JPH0797506A
1
JPH09279063A
1
JPH0959546A
1
JPH1017335A
1
JPH10204126A
1
JPH10204344A
1
JPH1036813A
1
JPH107884A
1
JPS53706A
1
JPS5829814A
1
JPS59168076A
1
JPS5980473A
1
JPS61164777A
1
JPS6377833A
1
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:50:07 GMT 2025
Edited
by admin
on Mon Mar 31 17:50:07 GMT 2025
Record UNII
A1A1I8X02B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHOXYDIGLYCOL
INCI  
INCI  
Preferred Name English
DIETHYLENE GLYCOL MONOETHYL ETHER
EP   HSDB   II   MI   USP-RS  
Systematic Name English
CARBITOL
Brand Name English
DIETHYLENE GLYCOL MONOETHYL ETHER [USP-RS]
Common Name English
DIETHYLENEGLYCOL MONOETHYL ETHER
Systematic Name English
2-(2-ETHOXYETHOXY)ETHANOL
Systematic Name English
DIETHYLENE GLYCOL MONOETHYL ETHER [MI]
Common Name English
DIETHYLENE GLYCOL MONOETHYL ETHER [EP MONOGRAPH]
Common Name English
NSC-408451
Code English
ETHANOL, 2-(2-ETHOXYETHOXY)-
Systematic Name English
TRANSCUTOL
Brand Name English
DIETHYLENE GLYCOL MONOETHYL ETHER [HSDB]
Common Name English
DIETHYLENE GLYCOL MONOETHYL ETHER [II]
Common Name English
Diethylene glycol monoethyl ether [WHO-DD]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 11504
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
Code System Code Type Description
RXCUI
1311147
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY RxNorm
WIKIPEDIA
2-(2-ETHOXYETHOXY)ETHANOL
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
CAS
111-90-0
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
PUBCHEM
8146
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
NSC
408451
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
ChEMBL
CHEMBL1230841
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
NCI_THESAURUS
C65380
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
ECHA (EC/EINECS)
203-919-7
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
MESH
C010111
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
EPA CompTox
DTXSID2021941
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
HSDB
50
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
EVMPD
SUB42639
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
EVMPD
SUB11902MIG
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
RS_ITEM_NUM
1193301
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
MERCK INDEX
m4404
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY Merck Index
FDA UNII
A1A1I8X02B
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
CONCEPT Industrial Aid
SMS_ID
100000076096
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
CHEBI
40572
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
DAILYMED
A1A1I8X02B
Created by admin on Mon Mar 31 17:50:07 GMT 2025 , Edited by admin on Mon Mar 31 17:50:07 GMT 2025
PRIMARY
Related Record Type Details
Structure of DIETHYLENE GLYCOL MONOETHYL ETHER
ACTIVE MOIETY
NIH
NCATS
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