Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C20H28FN3O3 |
Molecular Weight | 377.453 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@H](N)[C@H](CN1CCC3=CC(OC)=C(OC)C=C23)N4C[C@@H](CF)CC4=O
InChI
InChIKey=GUYMHFIHHOEFOA-ZCPGHIKRSA-N
InChI=1S/C20H28FN3O3/c1-26-18-6-13-3-4-23-11-17(24-10-12(9-21)5-20(24)25)15(22)8-16(23)14(13)7-19(18)27-2/h6-7,12,15-17H,3-5,8-11,22H2,1-2H3/t12-,15+,16+,17+/m1/s1
Molecular Formula | C20H28FN3O3 |
Molecular Weight | 377.453 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Carmegliptin is a potent, long-acting, selective, orally bioavailable, pyrrolidinone-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. ). DPP-IV is a proline-specific serine protease enzyme that is known to rapidly inactivate two incretin hormones released during food ingestion, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Incretins are essential for regulating both fasting and postprandial plasma glucose by stimulating insulin secretion, supporting β-cell mass, and inhibiting glucagon production by the α-cells to reduce glucose production by the liver. By selectively inhibiting DPP-IV, carmegliptin prolongs the activity of circulating GLP-1 and GIP and improves their potential to prolong the antidiabetic actions. Carmegliptin is indicated for use as monotherapy or in combination with other oral antihyperglycemic agents for the treatment of Type 2 diabetes.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26517136
dog: 2.5mg/kg
Monkey: 3.0mg/kg
Rat: 2.0mg/kg
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:30:48 UTC 2023
by
admin
on
Fri Dec 15 16:30:48 UTC 2023
|
Record UNII |
9Z723VGH7J
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C98086
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
8914
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
11417567
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
300000034126
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
813452-18-5
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
UU-93
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
C81698
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
CHEMBL591118
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
DB12268
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
9Z723VGH7J
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
DTXSID401001938
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY | |||
|
C552198
Created by
admin on Fri Dec 15 16:30:48 UTC 2023 , Edited by admin on Fri Dec 15 16:30:48 UTC 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |