KB-130015

CC1=C(CC2=CC(I)=C(OCC(O)=O)C(I)=C2)C3=C(O1)C=CC=C3

InChIKey=OLIKCJUMYWSDIV-UHFFFAOYSA-N

InChI=1S/C18H14I2O4/c1-10-13(12-4-2-3-5-16(12)24-10)6-11-7-14(19)18(15(20)8-11)23-9-17(21)22/h2-5,7-8H,6,9H2,1H3,(H,21,22)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen.	2010-09-02	20824064
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism.	2010-04-25	20097192
The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle.	2007-01-26	17134694
Inhibition of G protein-coupled and ATP-sensitive potassium currents by 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an amiodarone derivative.	2004-01	14569071
Slowing of the inactivation of cardiac voltage-dependent sodium channels by the amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015).	2003-01	12490583
Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone.	2002-01-31	11806713

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:50:11 GMT 2025` Edited by `admin` on `Mon Mar 31 21:50:11 GMT 2025`
Record UNII	9YA9HD8JR2
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

ACETIC ACID, 2-(2,6-DIIODO-4-((2-METHYL-3-BENZOFURANYL)METHYL)PHENOXY)-

Preferred Name

English

KB-130015

Common Name

English

Code System Code Type Description

PUBCHEM

9872203

Created by admin on Mon Mar 31 21:50:11 GMT 2025 , Edited by admin on Mon Mar 31 21:50:11 GMT 2025

PRIMARY

FDA UNII

9YA9HD8JR2

Created by admin on Mon Mar 31 21:50:11 GMT 2025 , Edited by admin on Mon Mar 31 21:50:11 GMT 2025

PRIMARY

CAS

147030-48-6

Created by admin on Mon Mar 31 21:50:11 GMT 2025 , Edited by admin on Mon Mar 31 21:50:11 GMT 2025

PRIMARY

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