PROPIKACIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H43N5O12
Molecular Weight	557.5924
Optical Activity	UNSPECIFIED
Defined Stereocenters	15 / 15
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](NC(CO)CO)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O

InChI

InChIKey=ZEFUFVWPRPISAD-FLUPTLLOSA-N

InChI=1S/C21H43N5O12/c22-2-9-14(31)15(32)12(25)20(35-9)37-18-7(23)1-8(26-6(3-27)4-28)19(17(18)34)38-21-16(33)11(24)13(30)10(5-29)36-21/h6-21,26-34H,1-5,22-25H2/t7-,8+,9+,10+,11-,12+,13+,14+,15+,16+,17-,18+,19-,20+,21+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H43N5O12
Molecular Weight	557.5924
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	15 / 15
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/528375 | https://www.ncbi.nlm.nih.gov/pubmed/6775590 | https://www.ncbi.nlm.nih.gov/pubmed/528375

Propikacin (also known as UK31214) is kanamycin B derivative patented by Pfizer Inc. as antibacterial compound. In preclinical studies Propikacin shows antibacterial activity against the Enterobacteriaceae, P. stuartii strains and the gentamicin-resistant strains of P. aeruginosa.

Originator

Approval Year

PubMed

Title	Date	PubMed
Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214).	1979 Oct	528375

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:58 GMT 2023` Edited by `admin` on `Fri Dec 15 16:06:58 GMT 2023`
Record UNII	9X6F5H479X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROPIKACIN

Official Name

English

UK-31,214

Code

English

PROPIKACIN [USAN]

Common Name

English

UK-31214

Code

English

propikacin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2363