TIRACIZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25N3O3
Molecular Weight	367.4415
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TIRACIZINE

Structure Search

SMILES

CCOC(=O)NC1=CC2=C(CCC3=CC=CC=C3N2C(=O)CN(C)C)C=C1

InChI

InChIKey=KJAMZCVTJDTESW-UHFFFAOYSA-N

InChI=1S/C21H25N3O3/c1-4-27-21(26)22-17-12-11-16-10-9-15-7-5-6-8-18(15)24(19(16)13-17)20(25)14-23(2)3/h5-8,11-13H,4,9-10,14H2,1-3H3,(H,22,26)

HIDE SMILES / InChI

Molecular Formula	C21H25N3O3
Molecular Weight	367.4415
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9412062 | https://www.ncbi.nlm.nih.gov/pubmed/8527691

Tiracizine a drug belongs to the new class I antiarrhythmic agent was studied in patients with ischemic heart disease, where was shown, that the drug could decrease myocardial contractile function.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Use dependent depression of fast sodium current in heart muscle by the new antiarrhythmic substance Bonnecor (AWD 19-166, GS 015).	1985 Dec	2419929

Patents

Patents

Sample Use Guides

In Vivo Use Guide

7-day multiple-dose study period (50 mg tiracizine twice daily)

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:19:43 GMT 2023` Edited by `admin` on `Sat Dec 16 17:19:43 GMT 2023`
Record UNII	9UUO2T61K7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TIRACIZINE

Official Name

English

Tiracizine [WHO-DD]

Common Name

English

tiracizine [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC01EB11

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

WHO-ATC

C01EB11

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

NCI_THESAURUS

C47793

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

Code System Code Type Description

FDA UNII

9UUO2T61K7

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

DRUG CENTRAL

2679

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

ChEMBL

CHEMBL1625260

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

MESH

C048166

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

INN

6494

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

CAS

83275-56-3

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

DRUG BANK

DB13635

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

EPA CompTox

DTXSID5048714

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

WIKIPEDIA

TIRACIZINE

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

PUBCHEM

71264

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

NCI_THESAURUS

C75137

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

EVMPD

SUB11114MIG

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

SMS_ID

100000077265

Created by admin on Sat Dec 16 17:19:43 GMT 2023 , Edited by admin on Sat Dec 16 17:19:43 GMT 2023

PRIMARY

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					9UUO2T61K7

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