ZINVIROXIME

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H18N4O3S
Molecular Weight	358.415
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)S(=O)(=O)N1C(N)=NC2=C1C=C(C=C2)C(=N/O)\C3=CC=CC=C3

InChI

InChIKey=IWKXBHQELWQLHF-SILNSSARSA-N

InChI=1S/C17H18N4O3S/c1-11(2)25(23,24)21-15-10-13(8-9-14(15)19-17(21)18)16(20-22)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H2,18,19)/b20-16-

HIDE SMILES / InChI

Molecular Formula	C17H18N4O3S
Molecular Weight	358.415
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7769678 | https://www.ncbi.nlm.nih.gov/pubmed/30219827 | https://www.ncbi.nlm.nih.gov/pubmed/10950388 | https://www.ncbi.nlm.nih.gov/pubmed/22945356

Enviroxime (LY 122772 or 2-amino-1-(isopropyl sulphonyl)-6-benzimidazole phenyl ketone oxime) is an benzimidazole antiviral agent. Enviroxime inhibits the replication of rhinoviruses and enteroviruses, additionally it impedes the replication of the hepatitis C virus. Enviroxime targets the 3A coding region of rhinovirus and poliovirus. Enviroxime is able to inhibit host phosphatidylinositol 4-kinase III.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Human rhinovirus 1B 2 Target ID: CHEMBL613713 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9154972	Inhibitor 8504	40.0 nM [IC50]
viral protein 3A 2 Target ID: viral protein 3A Sources: https://www.ncbi.nlm.nih.gov/pubmed/21177810\|https://www.ncbi.nlm.nih.gov/pubmed/7769678	Inhibitor 8504
PI4-kinase beta subunit 3 Target ID: CHEMBL3268 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22945356\|https://www.ncbi.nlm.nih.gov/pubmed/21177810	Inhibitor 8504

PubMed

Title	Date	PubMed
Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: design, synthesis, and biological evaluation.	2003-09-25	13678411
Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication.	1999-08	10430536
Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime.	1997-05-09	9154972
Simple in vitro translation assay to analyze inhibitors of rhinovirus proteases.	1996-01	8787922
Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.	1990-06	1699494
Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides.	1990-02	2160796
9-Benzyl-6-(dimethylamino)-9H-purines with antirhinovirus activity.	1988-10	2845083
A 'new' generation of more potent synthetic antirhinovirus compounds: comparison of their MICs and their synergistic interactions.	1987-11	2833156
Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplication.	1980-04	6247489

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:29:44 GMT 2025` Edited by `admin` on `Wed Apr 02 08:29:44 GMT 2025`
Record UNII	9SWB3P2O2S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZINVIROXIME

Official Name

English

zinviroxime [INN]

Preferred Name

English

1H-BENZIMIDAZOL-2-AMINE, 6-((HYDROXYIMINO)PHENYLMETHYL)-1-((1-METHYLETHYL)SULFONYL)-, (Z)-

Common Name

English

(Z)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime

Systematic Name

English

ZINVIROXIME [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C281