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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H12O7
Molecular Weight 304.2522
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAXIFOLIN

SMILES

c1cc(c(cc1[C@]2([H])[C@]([H])(C(=O)c3c(cc(cc3O2)O)O)O)O)O

InChI

InChIKey=CXQWRCVTCMQVQX-LSDHHAIUSA-N
InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

HIDE SMILES / InChI

Molecular Formula C15H12O7
Molecular Weight 304.2522
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Dihydroquercetin (also known as taxifolin) is a flavonoid found in grapes, citrus fruits, onions, green tea, olive oil, and several herbs (such as milk thistle). Besides its antitumor, hepatoprotective, and anti-inflammatory activities, it is a potent antioxidant, which may contribute to its cardiovascular and neuroprotective properties. The drug was tested in vitro against cancer cells and in vivo, in preclinical models of liver diseases and cardiovascular diseases. The possible mechanism of actions involves the induction of phase II detoxifying enzymes and the suppression of cytochrome P450-dependent monooxygenases, apoptosis and disruption of cancer cell cycle progression.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

In a preclinical study, rats with hepatitis were given 100 mg/kg dihydroquercetin s.c. for 4 days.
Route of Administration: Other
in a MTT cytotoxicity assay, HCT116 cells (1*10(4) cells per well) were plated onto 96-well plates, incubated at 37C for 24 h, and the cells were treated with various concentrations of dihydroquercetin (3.9-250 uM). After 24 h, 10 ml of CCK-8 solution was added to the wells, and incubation continued for another 3 h.
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:37:38 UTC 2021
Edited
by admin
on Sat Jun 26 14:37:38 UTC 2021
Record UNII
9SOB9E3987
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TAXIFOLIN
Common Name English
(+)-TAXIFOLIN
Common Name English
(+)-TAXIFOLIN (CONSTITUENT OF MILK THISTLE) [DSC]
Common Name English
2,3-DIHYDROQUERCETIN
Common Name English
3,5,7,3',4'-PENTAHYDROXYFLAVANONE
Systematic Name English
4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-2,3-DIHYDRO-3,5,7-TRIHYDROXY-, (2R-TRANS)-
Systematic Name English
(+)-DIHYDROQUERCETIN
Common Name English
LAVITOL
Brand Name English
DIQUERTIN
Common Name English
FLAMENA D
Common Name English
DIHYDROQUERCETIN
INCI   WHO-DD  
INCI  
Official Name English
DIHYDROQUERCETIN [WHO-DD]
Common Name English
DIHYDROQUERCETIN [INCI]
Common Name English
DISTYLIN
Common Name English
FLAMENA
Common Name English
DIHYDROQUERCETIN, (+)-(2R,3R)-
Common Name English
(2R,3R)-(+)-TAXIFOLIN
Common Name English
(2R,3R)-3,3',4',5,7-PENTAHYDROXYFLAVANONE
Systematic Name English
TAXIFOLIOL
Common Name English
4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-2,3-DIHYDRO-3,5,7-TRIHYDROXY-, (2R,3R)-
Systematic Name English
(+)-(2R,3R)-DIHYDROQUERCETIN
Common Name English
(+)-TAXIFOLIN (CONSTITUENT OF MARITIME PINE) [DSC]
Common Name English
(2R,3R)-DIHYDROQUERCETIN
Common Name English
FLAVANONE, 3,3',4',5,7-PENTAHYDROXY-
Systematic Name English
Classification Tree Code System Code
DSLD 3966 (Number of products:3)
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
Code System Code Type Description
CAS
480-18-2
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
ECHA (EC/EINECS)
207-543-4
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
MESH
C003377
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
PUBCHEM
439533
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
WIKIPEDIA
Taxifolin
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
EPA CompTox
480-18-2
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
DRUG BANK
DB02224
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
FDA UNII
9SOB9E3987
Created by admin on Sat Jun 26 14:37:38 UTC 2021 , Edited by admin on Sat Jun 26 14:37:38 UTC 2021
PRIMARY
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