TAXIFOLIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H12O7
Molecular Weight	304.2522
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

c1cc(c(cc1[C@]2([H])[C@]([H])(C(=O)c3c(cc(cc3O2)O)O)O)O)O

InChI

InChIKey=CXQWRCVTCMQVQX-LSDHHAIUSA-N

InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C15H12O7
Molecular Weight	304.2522
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22513183

Dihydroquercetin (also known as taxifolin) is a flavonoid found in grapes, citrus fruits, onions, green tea, olive oil, and several herbs (such as milk thistle). Besides its antitumor, hepatoprotective, and anti-inflammatory activities, it is a potent antioxidant, which may contribute to its cardiovascular and neuroprotective properties. The drug was tested in vitro against cancer cells and in vivo, in preclinical models of liver diseases and cardiovascular diseases. The possible mechanism of actions involves the induction of phase II detoxifying enzymes and the suppression of cytochrome P450-dependent monooxygenases, apoptosis and disruption of cancer cell cycle progression.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Cancer 188 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22513183	Primary	Basic research	Unknown Approved Use Unknown
Cardiovascular diseases 31 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22513183	Primary	Preclinical	Unknown Approved Use Unknown
Liver diseases 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22513183	Primary	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

In a preclinical study, rats with hepatitis were given 100 mg/kg dihydroquercetin s.c. for 4 days.

Route of Administration: Other

In Vitro Use Guide

in a MTT cytotoxicity assay, HCT116 cells (1*10(4) cells per well) were plated onto 96-well plates, incubated at 37C for 24 h, and the cells were treated with various concentrations of dihydroquercetin (3.9-250 uM). After 24 h, 10 ml of CCK-8 solution was added to the wells, and incubation continued for another 3 h.

Substance Class	Chemical Created by `admin` on `Sat Jun 26 14:37:38 UTC 2021` Edited by `admin` on `Sat Jun 26 14:37:38 UTC 2021`
Record UNII	9SOB9E3987
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAXIFOLIN

Common Name

English

(+)-TAXIFOLIN

Common Name

English

(+)-TAXIFOLIN (CONSTITUENT OF MILK THISTLE) [DSC]

Common Name

English

2,3-DIHYDROQUERCETIN

Common Name

English

3,5,7,3',4'-PENTAHYDROXYFLAVANONE

Systematic Name

English

4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-2,3-DIHYDRO-3,5,7-TRIHYDROXY-, (2R-TRANS)-

Systematic Name

English

(+)-DIHYDROQUERCETIN

Common Name

English

LAVITOL

Brand Name

English

DIQUERTIN

Common Name

English

FLAMENA D

Common Name

English

DIHYDROQUERCETIN

Official Name

English

DIHYDROQUERCETIN [WHO-DD]

Common Name

English

DIHYDROQUERCETIN [INCI]

Common Name

English

DISTYLIN

Common Name

English

FLAMENA

Common Name

English

DIHYDROQUERCETIN, (+)-(2R,3R)-

Common Name

English

(2R,3R)-(+)-TAXIFOLIN

Common Name

English

(2R,3R)-3,3',4',5,7-PENTAHYDROXYFLAVANONE

Systematic Name

English

TAXIFOLIOL

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-2,3-DIHYDRO-3,5,7-TRIHYDROXY-, (2R,3R)-

Systematic Name

English

(+)-(2R,3R)-DIHYDROQUERCETIN

Common Name

English

(+)-TAXIFOLIN (CONSTITUENT OF MARITIME PINE) [DSC]

Common Name

English

(2R,3R)-DIHYDROQUERCETIN

Common Name

English

FLAVANONE, 3,3',4',5,7-PENTAHYDROXY-

Systematic Name

English

Classification Tree Code System Code

DSLD

3966 (Number of products:3)