BINIFIBRATE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H23ClN2O7
Molecular Weight	498.912
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(=O)OC(COC(=O)C2=CC=CN=C2)COC(=O)C3=CN=CC=C3

InChI

InChIKey=BFYRHDVAEJIBON-UHFFFAOYSA-N

InChI=1S/C25H23ClN2O7/c1-25(2,35-20-9-7-19(26)8-10-20)24(31)34-21(15-32-22(29)17-5-3-11-27-13-17)16-33-23(30)18-6-4-12-28-14-18/h3-14,21H,15-16H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C25H23ClN2O7
Molecular Weight	498.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6684439

Binifibrate is an anti-arteriosclerotic and hypolipidaemic agent. It was used under the name Biniwas in patients with hyperlipidemia, however, it is currently withdrawn from the market.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hyperlipidemia 82 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2104097	Primary		Approved 8583	BINIWAS Approved Use Hyperlipidemia.

PubMed

Title	Date	PubMed
Biotransformation kinetic of binifibrate and identification of its metabolites.	1991-05	1760151
[Changes in blood viscosity and erythrocyte deformability in patients with dyslipidemia treated with binifibrate].	1990-10	2104097
Microhaemorheological properties of binifibrate. Part I: Experimental studies.	1983	6684439
Microhaemorheological properties of binifibrate. Part II: Preliminary open studies in patients with peripheral arteriopathies.	1983	6684440

Sample Use Guides

In Vivo Use Guide

The recommended dose is 600 mg three times daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:04 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:04 GMT 2025`
Record UNII	9NGZ4GPE20
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BINIFIBRATE

Official Name

English

BINIWAS

Preferred Name

English

binifibrate [INN]

Common Name

English

Binifibrate [WHO-DD]

Common Name

English

BINIFIBRATE [MART.]

Common Name

English

BINIFIBRATE [MI]

Common Name

English

2-(P-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ESTER WITH 1,3-DINICOTININOYLOXY-2-PROPANOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150