BORNAPRINE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C21H31NO2
Molecular Weight	329.4763
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCCOC(=O)C1(C[C@@H]2CC[C@H]1C2)C3=CC=CC=C3

InChI

InChIKey=BDNMABJZSXTKAQ-VCPDFFEISA-N

InChI=1S/C21H31NO2/c1-3-22(4-2)13-8-14-24-20(23)21(18-9-6-5-7-10-18)16-17-11-12-19(21)15-17/h5-7,9-10,17,19H,3-4,8,11-16H2,1-2H3/t17-,19+,21?/m1/s1

HIDE SMILES / InChI

Molecular Formula	C21H31NO2
Molecular Weight	329.4763
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	2 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2057518 | https://www.ncbi.nlm.nih.gov/pubmed/7945741 | https://www.ncbi.nlm.nih.gov/pubmed/3514543 | https://www.ncbi.nlm.nih.gov/pubmed/3320624

Bornaptine is a synthetic anticholinergic drug. The compound is a nonselective M1 and M4 antagonist and was shown to inhibit the negative inotropic response to carbachol in the isolated left atrium of the rat with pA2 of 7.27. Bornaprine is used for the treatment of symptoms of Parkinson's disease. A clinical trial showed the superiority of Bornaprine over placebo in reducing parkinsonian tremor. Bornaptine demonstrated positive results in localized hyperhidrosis.

Approval Year

PubMed

Title	Date	PubMed
[Rhabdomyolysis as a complication of Parkinson's disease].	2002 Jan-Feb	12165940
Anticholinergics for symptomatic management of Parkinson's disease.	2003	12804486
Hyperhidrosis treatment with bornaprine in the acute phase of spinal cord-injured patients.	2008 Aug	18332889

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:34:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:34:21 GMT 2023`
Record UNII	9M363FGA7J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BORNAPRINE

Official Name

English

Bornaprine [WHO-DD]

Common Name

English

3-(DIETHYLAMINO)PROPYL 2-PHENYL-2-NORBORNANECARBOXYLATE

Systematic Name

English

bornaprine [INN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

N04AA11