Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C28H31NO5 |
| Molecular Weight | 461.5505 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cc1ccc(cc1)C(=O)Oc2ccc(cc2OC(=O)c3ccc(C)cc3)C(CNC(C)(C)C)O
InChI
InChIKey=FZGVEKPRDOIXJY-UHFFFAOYSA-N
InChI=1S/C28H31NO5/c1-18-6-10-20(11-7-18)26(31)33-24-15-14-22(23(30)17-29-28(3,4)5)16-25(24)34-27(32)21-12-8-19(2)9-13-21/h6-16,23,29-30H,17H2,1-5H3
| Molecular Formula | C28H31NO5 |
| Molecular Weight | 461.5505 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Bitolterol is a beta 2-adrenergic agonist. Since it in itself is biologically inactive, bitolterol is considered a pro-drug. When administered it is activated within the lung by esterase hydrolysis to the active compound colterol catecholamine N-t-butyl-arterenol. Bitolterol was marked under the name tornalate and was indicated to prevent and treat of reversible bronchospasm associated with asthma or chronic obstructive pulmonary diseases. But that drug was withdrawn from the market by Elan Pharmaceuticals in 2001.
Approval Year
Sample Use Guides
Acute Bronchospasm: adults and children older than 12 yr of age: oral inhalation 2 inhalations at interval of 1 to 3 min, followed by third inhalation if necessary.
Prevention of Bronchospasm: adults and children older than 12 yr of age: oral inhalation 2 inhalations every 8 h, not to exceed 3 inhalations every 6 h or 2 inhalations every 4 h.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 13:02:05 UTC 2021
by
admin
on
Sat Jun 26 13:02:05 UTC 2021
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| Record UNII |
9KY0QXD6LI
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C48149
Created by
admin on Sat Jun 26 13:02:05 UTC 2021 , Edited by admin on Sat Jun 26 13:02:05 UTC 2021
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WHO-VATC |
QR03AC17
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LIVERTOX |
112
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WHO-ATC |
R03AC17
Created by
admin on Sat Jun 26 13:02:05 UTC 2021 , Edited by admin on Sat Jun 26 13:02:05 UTC 2021
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NCI_THESAURUS |
C319
Created by
admin on Sat Jun 26 13:02:05 UTC 2021 , Edited by admin on Sat Jun 26 13:02:05 UTC 2021
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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M2578
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PRIMARY | Merck Index | ||
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384
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PRIMARY | |||
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C65267
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PRIMARY | |||
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35330
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PRIMARY | |||
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SUB05860MIG
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PRIMARY | |||
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30392-40-6
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PRIMARY | |||
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3855
Created by
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PRIMARY | |||
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19499
Created by
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PRIMARY | RxNorm | ||
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30392-40-6
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PRIMARY | |||
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CHEMBL1201295
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PRIMARY | |||
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C011685
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PRIMARY | |||
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DB00901
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PRIMARY | |||
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9KY0QXD6LI
Created by
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PRIMARY | |||
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BITOLTEROL
Created by
admin on Sat Jun 26 13:02:05 UTC 2021 , Edited by admin on Sat Jun 26 13:02:05 UTC 2021
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PRIMARY | |||
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Bitolterol
Created by
admin on Sat Jun 26 13:02:05 UTC 2021 , Edited by admin on Sat Jun 26 13:02:05 UTC 2021
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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SALT/SOLVATE -> PARENT | |||
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TARGET -> AGONIST |
SHORT-ACTING
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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METABOLITE ACTIVE -> PRODRUG |
