CJ-033466

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H28ClN5O
Molecular Weight	377.912
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN1CCC(CNC(=O)C2=CC(Cl)=C(N)N3C=C(C)N=C23)CC1

InChI

InChIKey=ISKHMDNIWXPUGR-UHFFFAOYSA-N

InChI=1S/C19H28ClN5O/c1-12(2)10-24-6-4-14(5-7-24)9-22-19(26)15-8-16(20)17(21)25-11-13(3)23-18(15)25/h8,11-12,14H,4-7,9-10,21H2,1-3H3,(H,22,26)

HIDE SMILES / InChI

Molecular Formula	C19H28ClN5O
Molecular Weight	377.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18198343

CJ-033466 is experimental drug, which acts as selective 5-HT4 serotonin receptor partial agonist. It was originally synthesized at Pfizer Laboratories, and it was specifically exemplified in Pfizer patent applications (WO2003035649 and WO2004026869). In animal tests, it stimulated gastrointestinal motility with 30 times the potency of cisapride. CJ-033,466 does not affect D2 and other 5-HT receptors, and it is a potential therapy for gastroparesis patients.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 4 (5-HT4) receptor 39 Target ID: CHEMBL1875 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18198343	Partial Agonist 290

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gastroparesis 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18198343	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: a novel 5-HT4 partial agonist.	2008 Oct	18271033

Patents

Sample Use Guides

In Vivo Use Guide

CJ-033,466 was administered orally to beagle dogs at 0.03 mg/kg

Route of Administration: Oral

In Vitro Use Guide

Human 5-HT4d was transfected to HEK293 cells. To evaluate functional effect of the drug, Intracellular cAMP production was measured by fluorimetry. EC50 of CJ-033466 was 0.927 nM, Emax 54% compared to 5-HT.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:24:53 UTC 2023` Edited by `admin` on `Sat Dec 16 08:24:53 UTC 2023`
Record UNII	9KUW8W70PJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CJ-033466

Common Name

English

IMIDAZO(1,2-A)PYRIDINE-8-CARBOXAMIDE, 5-AMINO-6-CHLORO-2-METHYL-N-((1-(2-METHYLPROPYL)-4-PIPERIDINYL)METHYL)-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID00199882