DIMETHYL SULFITE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6O3S
Molecular Weight	110.132
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COS(=O)OC

InChI

InChIKey=BDUPRNVPXOHWIL-UHFFFAOYSA-N

InChI=1S/C2H6O3S/c1-4-6(3)5-2/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6O3S
Molecular Weight	110.132
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27048678 | https://www.ncbi.nlm.nih.gov/pubmed/8519792 | DOI: 10.1016/j.tet.2015.09.075

Dimethyl sulfate (DMS) is a diester of methanol and sulfurous acid. Dimethyl sulfate is a potential reagent for the methylation. It is a substrate for sulfite oxidase. Dimethyl sulfate is stable in blood and can be transported from the intestines to the alveoli and the air. Therefore, DMS in the blood is accepted as a marker of halitosis. The high DMS levels in systemic circulation detected in the multicenter case-control clinical study of laryngopharyngeal reflux.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
sulfite oxidase 1 Target ID: 1.07055408E8 Gene Symbol: SUOX Sources: https://www.ncbi.nlm.nih.gov/pubmed/8519792	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Laryngopharyngeal reflux 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27048678	Diagnostic		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Impairment of olfactory perception in male rats by treatment with p-chlorophenylalanine and hydrocortisone.	1978	155004
The reaction of chicken liver sulfite oxidase with dimethylsulfite.	1995 Dec 6	8519792
Analysis of the possible altering function of the septal organ in rats: a lesional and behavioral study.	1995 Nov	8577878
Derivatisation in gas chromatographic determination of acidic herbicides in aqueous environmental samples.	2003 Oct	12904959
Matrix isolation FTIR spectroscopic and theoretical study of dimethyl sulfite.	2005 Apr 28	16839024
A tale of two oxidation states: bacterial colonization of arsenic-rich environments.	2007 Apr 13	17432936
[Effect of design and operation parameters on volatile alkylsulfides removal in subsurface constructed wetlands].	2010 Feb	20391700
Laryngopharyngeal Reflux Has Negative Effects on Taste and Smell Functions.	2016 Jul	27048678

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:45:57 GMT 2023` Edited by `admin` on `Fri Dec 15 19:45:57 GMT 2023`
Record UNII	9JFA40S66P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIMETHYL SULFITE

Systematic Name

English

METHOXYSULFINYLOXYMETHANE

Systematic Name

English

SULFUROUS ACID, DIMETHYL ESTER

Common Name

English

NSC-41902

Code

English

Code System Code Type Description

PUBCHEM

69223