Details
Stereochemistry | ACHIRAL |
Molecular Formula | Sb |
Molecular Weight | 121.76 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Sb]
InChI
InChIKey=OUULRIDHGPHMNQ-UHFFFAOYSA-N
InChI=1S/Sb.3H
Molecular Formula | Sb |
Molecular Weight | 121.76 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Antimony (Sb) is a toxic metalloid that occurs widely at trace concentrations in soil, aquatic systems, and the atmosphere. Antimony is not an abundant element but is found in small quantities in over 100 mineral species. It is most often found as antimony(III) sulfide. Antimony is used in the electronics industry to make some semiconductor devices, such as infrared detectors and diodes. It is alloyed with lead or other metals to improve their hardness and strength. A lead-antimony alloy is used in batteries. Other uses of antimony alloys include type metal (in printing presses), bullets and cable sheathing. Antimony has been in medical use against microbes and parasites as well. Antimony-based drugs have been prescribed against leishmaniasis since the parasitic transmission of the tropical disease was understood in the beginning of the 20th century. As a therapeutic, antimony has been mostly used for the treatment of leishmaniasis and schistosomiasis. The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections.
Approval Year
PubMed
Title | Date | PubMed |
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Interleukin 6 during active visceral leishmaniasis and after treatment. | 1995 Oct |
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[American cutaneous leishmaniasis in the Federal District]. | 1999 Sep-Oct |
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Mucosal leishmaniasis: quantitative nasal cytology as a marker of disease activity and indicator of healing. | 2000 Jan |
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Mononuclear cell recruitment, granuloma assembly, and response to treatment in experimental visceral leishmaniasis: intracellular adhesion molecule 1-dependent and -independent regulation. | 2000 Nov |
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Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis. | 2000 Nov |
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Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels. | 2003 May 15 |
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Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam. | 2004 Sep 3 |
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Classification of heavy-metal toxicity by human DNA microarray analysis. | 2007 May 15 |
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Cutaneous leishmaniasis with boggy induration and simultaneous mucosal disease. | 2009 Jan |
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[An adult case of visceral leishmaniasis in a province of Black-Sea region, Turkey]. | 2010 Oct |
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Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis. | 2011 Jan |
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Solubility shift and SUMOylaltion of promyelocytic leukemia (PML) protein in response to arsenic(III) and fate of the SUMOylated PML. | 2015 Sep 15 |
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 17:17:42 UTC 2023
by
admin
on
Fri Dec 15 17:17:42 UTC 2023
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Record UNII |
9IT35J3UV3
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Record Status |
Validated (UNII)
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Record Version |
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DSLD |
3349 (Number of products:23)
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CFR |
21 CFR 862.3110
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NCI_THESAURUS |
C1940
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DTXSID5023879
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30304
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30513
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m1953
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DB13110
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D000965
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1311407
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5354495
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508
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100000077405
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9IT35J3UV3
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9IT35J3UV3
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C95187
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231-146-5
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SUB12914MIG
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7440-36-0
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Related Record | Type | Details | ||
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ACTIVE MOIETY |