Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H6O2S |
| Molecular Weight | 94.133 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(C)(=O)=O
InChI
InChIKey=HHVIBTZHLRERCL-UHFFFAOYSA-N
InChI=1S/C2H6O2S/c1-5(2,3)4/h1-2H3
| Molecular Formula | C2H6O2S |
| Molecular Weight | 94.133 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DIMETHYL SULFONE is a compound that contains sulfur. It is a naturally occurring organosulfur compound utilized as a complementary and alternative medicine (CAM) under a variety of names including dimethyl sulfone, methyl sulfone, sulfonylbismethane, organic sulfur, or crystalline dimethyl sulfoxide. Its most common use is as anti-inflammatory agent. DIMETHYL SULFONE has been claimed to relieve stress, relieve pain, treat parasitic infections, increase energy, boost metabolism, enhance circulation, and improve wound healing, but there is little supporting scientific evidence. Due to its enhanced ability to penetrate membranes and permeate throughout the body, the full mechanistic function of MSM may involve a collection of cell types and is therefore difficult to elucidate. DIMETHYL SULFONE is recognized as safe by the FDA, but efficacy has yet to be proven. In rats, no adverse events were observed after daily doses of 2 g MSM per kg of body weight. Published clinical trials of DIMETHYL SULFONE did not report any serious side effects, but long-term effects are unknown.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | ARTHRONSAN Approved UseUnknown Launch Date1.52254074E12 |
|||
| Inactive ingredient | Meloxicam Approved UseMeloxicam is a non-steroidal anti-inflammatory drug indicated for:
Osteoarthritis (OA) ( 1.1)
Rheumatoid Arthritis (RA) Launch Date1.27776955E12 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| PCB methyl sulphones in rat liver after exposure to PCB (Clophen A50): analysis and radiosynthesis of selected methylsulphonyl-PCBs. | 2001 Feb |
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| Metabolite of 2,2',4',5-tetrabromobiphenyl, 3-methylsulphonyl-2,2',4',5-tetrabromobiphenyl, a potent inducer of CYP2B1/2 in rat. | 2002 Apr |
|
| By the way, doctor. Is MSM as good as it sounds? Can you tell me anything about the dietary supplement MSM? I've heard it's supposed to relieve arthritis pain. | 2002 Aug |
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| The application of MAS recoupling methods in the intermediate motional regime. | 2002 Jul |
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| Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: more data needed on pollen counts and questionnaire. | 2002 Jun |
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| In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17beta-estradiol-induced gene expression in several bioassay systems. | 2002 Oct |
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| Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. | 2002 Sep 10 |
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| A CysB-regulated and sigma54-dependent regulator, SfnR, is essential for dimethyl sulfone metabolism of Pseudomonas putida strain DS1. | 2003 Apr |
|
| Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice. | 2003 Apr |
|
| Environmental VOSCs--formation and degradation of dimethyl sulfide, methanethiol and related materials. | 2004 Apr |
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| A prodrug approach to COX-2 inhibitors with methylsulfone. | 2004 Apr 5 |
|
| Molecular detection and isolation of facultatively methylotrophic bacteria, including Methylobacterium podarium sp. nov., from the human foot microflora. | 2004 Aug |
|
| In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. | 2004 Feb 12 |
|
| Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. | 2004 Jan 29 |
|
| Single laboratory validation of a method for determination of glucosamine in raw materials and dietary supplements containing glucosamine sulfate and/or glucosamine hydrochloride by high-performance liquid chromatography with FMOC-Su derivatization. | 2004 Sep-Oct |
|
| Molecular detection and isolation from antarctica of methylotrophic bacteria able to grow with methylated sulfur compounds. | 2005 Aug |
|
| Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR. | 2005 Aug |
|
| The sigma54-dependent transcriptional activator SfnR regulates the expression of the Pseudomonas putida sfnFG operon responsible for dimethyl sulphone utilization. | 2005 Feb |
|
| Influence of resonance on the acidity of sulfides, sulfoxides, sulfones, and their group 16 congeners. | 2005 Jun 9 |
|
| Catalytic ozonation of gaseous reduced sulfur compounds using wood fly ash. | 2005 Mar 15 |
|
| Kinetics studies of aqueous phase reactions of Cl atoms and Cl2(-) radicals with organic sulfur compounds of atmospheric interest. | 2005 May 5 |
|
| Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel. | 2006 Apr |
|
| Managing ichthyosis: a case study. | 2006 Apr |
|
| Levels of PCBs and their metabolites in the serum of residents of a highly contaminated area in eastern Slovakia. | 2006 Jun 15 |
|
| Catalytic oxidation processes for removing dimethylsulfoxide from wastewater. | 2007 Jun |
|
| Oral developmental toxicity study of methylsulfonylmethane in rats. | 2007 Jun |
|
| Why are dimethyl sulfoxide and dimethyl sulfone such good solvents? | 2008 Aug |
|
| A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio. | 2008 Jul 15 |
|
| Yeast as a model system for identification of metabolic targets of a 'glucosamine complex' used as a therapeutic agent of osteoarthritis. | 2008 Nov |
|
| Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. | 2008 Nov |
| Substance Class |
Chemical
Created
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9H4PO4Z4FT
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Validated (UNII)
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651 (Number of products:1171)
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C257
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2126 (Number of products:116)
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C84616
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229
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DTXSID4043937
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SUB16418MIG
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9349
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C025910
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23247
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9H4PO4Z4FT
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1437600
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9H4PO4Z4FT
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200-665-9
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METHYLSULFONYLMETHANE
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6213
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m4553
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100000091429
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63345
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67-71-0
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DB14090
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE |
Dimethyl sulfone is a normal oxidative metabolite product of dimethyl sulfoxide (DMSO) found in foods.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
