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Details

Stereochemistry ACHIRAL
Molecular Formula Ra
Molecular Weight 223.01849714
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of RADIUM RA-223 CATION

SMILES

[223Ra++]

InChI

InChIKey=PZDJSXWIQXZUBJ-OIOBTWANSA-N
InChI=1S/Ra/q+2/i1-3

HIDE SMILES / InChI

Molecular Formula Ra
Molecular Weight 223.01849714
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Radium Ra 223 dichloride is a radiotherapeutic drug that is approved for the treatment of male patients with symptoms of advanced prostate cancer with bone metastases. Ra 223 mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnover. The radioactive alpha particles emitted by radium Ra 223 helps in killing cancer cells in the bone by damaging their DNA. Radium Ra 223 causes minimal damage to the nearby healthy cells.

Originator

Approval Year

Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experience.
2008 Mar
A randomized, double-blind, dose-finding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castration-resistant prostate cancer.
2013 Feb
Phase I pharmacokinetic and biodistribution study with escalating doses of ²²³Ra-dichloride in men with castration-resistant metastatic prostate cancer.
2013 Sep
Patents

Sample Use Guides

In Vivo Use Guide
The dose regimen is 50 kBq (1.35 microcurie) per kg body weight, given at 4 week intervals for 6 injections.
Route of Administration: Intravenous
In Vitro Use Guide
Radium-223 dichloride showed a dose-dependent inhibition of MDA-MB-231(SA) breast cancer cell proliferation at concentrations of 400, 800 and 1600 Bq/mLcompared to the control in a 5-day in vitro proliferation assay
Substance Class Chemical
Created
by admin
on Tue Oct 22 18:39:28 UTC 2019
Edited
by admin
on Tue Oct 22 18:39:28 UTC 2019
Record UNII
9H414A99MD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RADIUM RA-223 CATION
Common Name English
RADIUM, ISOTOPE OF MASS 223 (223RA2+)
Common Name English
RADIUM-223 ION(2+)
Common Name English
Classification Tree Code System Code
NDF-RT N0000187053
Created by admin on Tue Oct 22 18:39:28 UTC 2019 , Edited by admin on Tue Oct 22 18:39:28 UTC 2019
Code System Code Type Description
RXCUI
1745075
Created by admin on Tue Oct 22 18:39:28 UTC 2019 , Edited by admin on Tue Oct 22 18:39:28 UTC 2019
PRIMARY
NDF-RT
N0000187052
Created by admin on Tue Oct 22 18:39:28 UTC 2019 , Edited by admin on Tue Oct 22 18:39:28 UTC 2019
PRIMARY alpha-Particle Emitting Activity [MoA]
Related Record Type Details
ACTIVE MOIETY