MIRISETRON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H31N3O2
Molecular Weight	393.5218
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CC[C@]([H])(C[C@@H](C1)NC(=O)C3=CN(C4CCCCC4)C5=CC=CC=C5C3=O)N2C

InChI

InChIKey=RFXHBILZLMJCSN-GGPHIMKMSA-N

InChI=1S/C24H31N3O2/c1-26-18-11-12-19(26)14-16(13-18)25-24(29)21-15-27(17-7-3-2-4-8-17)22-10-6-5-9-20(22)23(21)28/h5-6,9-10,15-19H,2-4,7-8,11-14H2,1H3,(H,25,29)/t16-,18+,19-

HIDE SMILES / InChI

Molecular Formula	C24H31N3O2
Molecular Weight	393.5218
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://adisinsight.springer.com/drugs/800003649 | https://www.ncbi.nlm.nih.gov/pubmed/8783389

Mirisetron (also known as WAY-100579) was developed as 5-HT3 receptor antagonist by Wyeth-Ayerst in the USA. This drug participated in clinical trials phase I for the treatment of anxiety disorders and for sleep disorders. In addition, in preclinical studies, the drug was used in cognition disorders. However, all these studies were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Comparison of the effects of the 5-HT3 receptor antagonists WAY-100579 and ondansetron on spatial learning in the water maze in rats with excitotoxic lesions of the forebrain cholinergic projection system.	1996 May	8783389
The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys.	1997 Jan-Feb	8983029

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:29:54 UTC 2023` Edited by `admin` on `Fri Dec 15 18:29:54 UTC 2023`
Record UNII	9H3O05X8UL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MIRISETRON

Official Name

English

Mirisetron [WHO-DD]

Common Name

English

mirisetron [INN]

Common Name

English

Code System Code Type Description

CAS

135905-89-4