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Details

Stereochemistry ACHIRAL
Molecular Formula C24H31N3O2
Molecular Weight 393.5218
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MIRISETRON

SMILES

[H][C@]12CC[C@]([H])(C[C@@H](C1)NC(=O)C3=CN(C4CCCCC4)C5=CC=CC=C5C3=O)N2C

InChI

InChIKey=RFXHBILZLMJCSN-GGPHIMKMSA-N
InChI=1S/C24H31N3O2/c1-26-18-11-12-19(26)14-16(13-18)25-24(29)21-15-27(17-7-3-2-4-8-17)22-10-6-5-9-20(22)23(21)28/h5-6,9-10,15-19H,2-4,7-8,11-14H2,1H3,(H,25,29)/t16-,18+,19-

HIDE SMILES / InChI

Molecular Formula C24H31N3O2
Molecular Weight 393.5218
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Mirisetron (also known as WAY-100579) was developed as 5-HT3 receptor antagonist by Wyeth-Ayerst in the USA. This drug participated in clinical trials phase I for the treatment of anxiety disorders and for sleep disorders. In addition, in preclinical studies, the drug was used in cognition disorders. However, all these studies were discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:29:54 GMT 2023
Edited
by admin
on Fri Dec 15 18:29:54 GMT 2023
Record UNII
9H3O05X8UL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MIRISETRON
INN   WHO-DD  
INN  
Official Name English
Mirisetron [WHO-DD]
Common Name English
mirisetron [INN]
Common Name English
Code System Code Type Description
CAS
135905-89-4
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
EVMPD
SUB08992MIG
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
NCI_THESAURUS
C174577
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110961
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
PUBCHEM
60931
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
MESH
C104926
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
FDA UNII
9H3O05X8UL
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
SMS_ID
100000080646
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
INN
7284
Created by admin on Fri Dec 15 18:29:55 GMT 2023 , Edited by admin on Fri Dec 15 18:29:55 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY