PRIDINOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO
Molecular Weight	295.4186
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CCN1CCCCC1)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=RQXCLMGKHJWMOA-UHFFFAOYSA-N

InChI=1S/C20H25NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1-2,4-7,10-13,22H,3,8-9,14-17H2

HIDE SMILES / InChI

Molecular Formula	C20H25NO
Molecular Weight	295.4186
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.mims.com/india/drug/info/pridinol?type=full&mtype=generic | https://www.ncbi.nlm.nih.gov/pubmed/12935797 | http://mmpharm1.tradekorea.com/product/detail/P260632/Skeletal-Muscle-Relaxants.html?minisiteprodgroupno=29432

Pridinol mesilate is a centrally acting muscle relaxant that is used in the symptomatic treatment of muscle spasm. It is also used as the hydrochloride salt for its antimuscarinic activity in the management of parkinsonism.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?D08418 \| https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+2684 \| https://www.ncbi.nlm.nih.gov/pubmed/8102927	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Muscle spasm 40 Sources: http://mmpharm1.tradekorea.com/product/detail/P260632/Skeletal-Muscle-Relaxants.html?minisiteprodgroupno=29432 https://www.ncbi.nlm.nih.gov/pubmed/12935797	Primary		Approved 8429	Pridinol Approved Use Muscle spasms

PubMed

Title	Date	PubMed
Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection.	2004 Oct	15490448
Validated stability-indicating HPLC method for the determination of pridinol mesylate. Kinetics study of its degradation in acid medium.	2008 Dec 1	18922659
Development and validation of an HPLC method for the determination of process-related impurities in pridinol mesylate, employing experimental designs.	2009 Nov 10	19854345
Development and validation of a dissolution test for meloxicam and pridinol mesylate from combined tablet formulation.	2010 Mar	20838523
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011 Jul 14	21599003

Patents

Sample Use Guides

In Vivo Use Guide

Oral Muscle spasms Adult: As mesilate: Usual initial: 2-8 mg tid; Maintenance: 4-8 mg daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:24 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:24 GMT 2023`
Record UNII	9E75Q6SUUB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRIDINOL

Official Name

English

PRIDINOL [HSDB]

Common Name

English

C-238

Code

English

Pridinol [WHO-DD]

Common Name

English

NSC-23016

Code

English

PRIDINOL [MI]

Common Name

English

pridinol [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM03BX03