ZOXAZOLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC2=C(O1)C=CC(Cl)=C2

InChI

InChIKey=YGCODSQDUUUKIV-UHFFFAOYSA-N

InChI=1S/C7H5ClN2O/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H,(H2,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H5ClN2O
Molecular Weight	168.58
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6467036 | https://www.ncbi.nlm.nih.gov/pubmed/10712246 | https://pdfs.semanticscholar.org/f719/c3d1867bf65a6e38e7dc5647447ebee506c7.pdf | https://www.ncbi.nlm.nih.gov/pubmed/14492563

Zoxazolamine is a centrally acting muscle relaxant. It decreased striatal dopamine metabolism without affecting striatal dopamine concentrations. More specifically, Zoxazolamine was shown to decrease striatal dopamine turnover without directly affecting dopamine synthesis, catabolism, reuptake, or release. It is the IK(Ca) channel opener. It was approved for the relief of muscle spasm in conditions such as musculoskeletal disorders and neurological diseases. Later, it was submitted for the drug's use as a uricosuric agent to treat gout. It was withdrawn from the market due to hepatotoxicity.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
dopamine metabolic process 5 Target ID: GO:0042417 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6467036	Inhibitor 8504
Intermediate conductance calcium-activated potassium channel protein 4 13 Target ID: CHEMBL4305 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10712246	Opener 34

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gout 28 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14462935 https://www.ncbi.nlm.nih.gov/pubmed/14492563 https://www.ncbi.nlm.nih.gov/pubmed/14038637	Primary		Withdrawn	Flexin Approved Use Zoxazolamine was indicated as a uricosuric agent to treat gout. Launch Date 1956
Muscle spasm 41 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13286127 https://www.ncbi.nlm.nih.gov/pubmed/13371252 https://www.ncbi.nlm.nih.gov/pubmed/13403149 https://www.ncbi.nlm.nih.gov/pubmed/13462734	Primary		Withdrawn	Flexin Approved Use Zoxazolamine was indicated for the relief of muscle spasm in conditions such as musculoskeletal disorders and neurological diseases Launch Date 1956

C_max

Value	Dose	Co-administered	Analyte	Population
7.5 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/13571254/	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:		ZOXAZOLAMINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
250 mg 4 times / day multiple, oral Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13726185	unhealthy, 40 years Health Status: unhealthy Age Group: 40 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/13726185	Disc. AE: Hepatitis... AEs leading to discontinuation/dose reduction: Hepatitis (acute, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13726185

AEs

AE	Significance	Dose	Population
Hepatitis	acute, 1 patient Disc. AE	250 mg 4 times / day multiple, oral Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13726185	unhealthy, 40 years Health Status: unhealthy Age Group: 40 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/13726185

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP1A1 389

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP1A1 389	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/8651703/	yes

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY563103	https://www.001chemical.com/chem/61-80-3
3B Scientific (Wuhan) Corp	3B3-018650	http://www.3bsc.com/index/pro_info.php?id=41174
AA Blocks	AA003MLP	http://www.aablocks.com/goods/Goods/detail?id=AA003MLP
Aaron Chemicals	AR003NDH	http://www.aaronchem.com/61-80-3
abcr GmbH	AB146024	http://www.abcr.com/shop/en/AB146024
AbMole Bioscience	M3142	http://www.abmole.com/products/zoxazolamine.html
Achemo Scientific Limited	AC-32519	http://www.achemo.com/product_view.asp?ID=36574
Achemtek	0104-010041	http://www.achemtek.com/61-80-3
Acros Organics	AC103380010	https://www.fishersci.com/shop/products/2-amino-5-chlorobenzoxazole-97-acros-organics/AC103380010
Acros Organics	AC103380050	https://www.fishersci.com/shop/products/2-amino-5-chlorobenzoxazole-97-acros-organics-1/AC103380050
Acros Organics	AC103380250	https://www.fishersci.com/shop/products/2-amino-5-chlorobenzoxazole-97-acros-organics-1/AC103380250
AHH Chemical co.,ltd	MT-33140	http://www.ahhchemical.com/product/MT-33140.html
AK Scientific, Inc. (AKSCI)	9267AB	http://www.aksci.com/item_detail.php?cat=9267AB
Alinda	ALBB-018399	http://alinda.ru/finechem_en_.html?i=ALBB-018399
Allbio Pharm Co., Ltd	AD03104	http://www.allbiopharm.com/product/n/AD03104
Ambinter	Amb1153987	http://www.ambinter.com/reference/1153987
Angene	AGN-PC-07Y50K	http://www.angenechemical.com/productshow/AGN-PC-07Y50K.html
Anward	ANW-58181	http://www.anward.com/pro_result/44632
ApexBio Technology	B1871	http://www.apexbt.com/zoxazolamine.html
AstaTech, Inc.	52984	http://www.astatechinc.com/CPSResult.php?CRNO=3492
Aurora Fine Chemicals LLC	A00.232.073	http://online.aurorafinechemicals.com/info?ID=A00.232.073
Aurum Pharmatech LLC	R1128	http://www.Aurumpharmatech.com/Product/ProductDetails/R1128
Avantor Inc	101181-818	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101181-818
Avantor Inc	200022-418	https://us.vwr.com/store/product/7513627/2-amino-5-chlorobenzoxazole-97
Avantor Inc	200040-814	https://us.vwr.com/store/product/7513627/2-amino-5-chlorobenzoxazole
BioCrick	BCC4751	http://www.biocrick.com/Zoxazolamine-BCC4751.html
BioSynth	J-517385	https://www.biosynth.com/en/products/all-products/products/J-517385.html
BLD Pharm	BD4370	http://www.bldpharm.com/products/61-80-3.html
BOC Sciences	61-80-3	https://buildingblock.bocsci.com/product/2-amino-5-chlorobenzoxazole-cas-61-80-3-323038.html
Capot Chemical	12473	http://www.capotchem.com/en/12473.htm
Capot Chemical	PubChem12473	http://www.capotchem.com/en/12473.htm
Chem Scene	CS-0013070	http://www.chemscene.com/61-80-3.html
ChemMol	49416527	http://www.chemmol.com/chemmol/49416527.html
ChemMol	99117832	http://www.chemmol.com/chemmol/99117832.html
Chemspace	CSSB00000198520	https://chem-space.com/CSSB00000198520
Clearsynth	CS-T-62858	https://www.clearsynth.com/en/CST62858.html
CSNpharm	CSN16887	https://www.csnpharm.com/products/zoxazolamine.html
DC Chemicals	DC36143	http://www.dcchemicals.com//product_show-AI3-63120.html
Debye Scientific	DB-027769	http://www.debyesci.com/DB-027769.html
eNovation Chemicals	D651370	https://www.enovationchem.com/ProductDetails.asp?ProductID=D651370
Hairui	HR102973	http://www.hairuichem.com/en/product/61-80-3.html
Heterocyclics Research Chemicals & Building blocks	JR-14592	http://www.heterocyclics.com/details.php?cat_id=JR-14592
Lab Network	LN00180136	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00180136
LGC Standards	LGCFOR3325.00	https://www.lgcstandards.com/US/en/p/LGCFOR3325.00
Matrix Scientific	81385	https://www.matrixscientific.com/081385.html
MedChem Express	HY-B1307	https://www.medchemexpress.com/Zoxazolamine.html
Molcore	MC563103	https://www.molcore.com/product/61-80-3
Oakwood	1002	http://www.oakwoodchemical.com/p-2-001002.aspx
OChem	6751	http://www.ocheminc.com/index.php?act=psearch&pid=005A770
Renno Tech	RL04341	http://www.rennotech.com/product_show.asp?id=4590
Sigma-Aldrich	A45807_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/a45807?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S565567	https://www.smolecule.com/products/s565567
THE BioTek	bt-295297	https://www.thebiotek.com/product/others/bt-295297
Vitas-M Laboratory	BBL023547	http://www.request.vitasmlab.biz/index.php?option=com_search_stk&Itemid=22&stk=BBL023547&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
VladaChem	VL277549-1G	https://www.vladachem.com/product.php?products=61-80-3

PubMed

Title	Date	PubMed
Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.	2015-03-20	25623066
Halogen, hydrogen and electrostatic interactions in 2-amino-5-chloro-1,3-benzoxazol-3-ium nitrate and 2-amino-5-chloro-1,3-benzoxazol-3-ium perchlorate.	2010-09	20814104
Bioenhancers: Revolutionary concept to market.	2010-04	21836795
12-(4-Chloro-phen-yl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one.	2010-02-06	21580318
9,9-Dimethyl-12-(4-nitro-phen-yl)-9,10-dihydro-12H-benzo[a]xanthen-11(8H)-one.	2009-11-21	21578862
9,9-Dimethyl-12-phenyl-8,9-dihydro-12H-benzo[a]xanthen-11(10H)-one.	2009-11-07	21578757
Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes.	2009-08	19489075
Anti-clastogenic effect of magnolol-containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on benzo(a)pyrene-induced clastogenicity in mice.	2009-07	19571387
Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice.	2009-07	19140158
Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).	2009-02-04	19041682
Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.	2008-10	18597044
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function.	2008-09	18690243
Alterations in xenobiotic metabolism in the long-lived Little mice.	2007-08	17521389
The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.	2007-08	17483497
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.	2007-06-28	17598905
Surgical correction of fixed kyphosis.	2007-06	20411147
Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity.	2007-05-22	17291700
Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver.	2007	17605299
Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice.	2006-10-15	16828826
Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.	2006-10	16841368
Effect of some biologically interesting substituted tetrahydro-1,4-oxazines on drug metabolising enzymes and on inflammation.	2005-10	16248839
Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.	2005-08-30	16109766
Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs.	2004-10-18	16125625
Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression.	2004-07	14985237
Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells.	2004-01	14648123
Inhibition of endothelium-dependent vasorelaxation by extracellular K(+): a novel controlling signal for vascular contractility.	2004-01	12969893
Effect of novel anti-inflammatory ethanolamine derivatives with antioxidant properties on drug metabolising enzymes.	2003-09-25	14503659
Effect of p-amino-diphenyl ethers on hepatic microsomal cytochrome P450.	2003-09	14531464
Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation.	2003-01-31	12421833
Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells.	2003-01-03	12480161
Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A.	2002-12	12393941
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.	2001-11	11602523
In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves.	2001-10	11883149
Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions.	2001-06	11469725
Hepatoprotective activity of indigtone--a bioactive fraction from Indigofera tinctoria Linn.	2001-06	11406850
Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.	2001-03	11181893
Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.	2001-01	11159756
Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.	2000-03	10712246
In-vivo effects of itraconazole on hepatic mixed-function oxidase.	1988-02	2452150
Effect of benzopyrone derivatives on drug activity and metabolism.	1986-10-01	3582421
The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.	1986-03	2856069
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.	1974-11	4418514

Patents

Sample Use Guides

In Vivo Use Guide

0.5 gm daily dose

Route of Administration: Oral

In Vitro Use Guide

Mouse aortic endothelial cells were loaded with 0.5 uM Ca2+ in the pipette and current measured at 50 and −50 mV during repetitive ramps and the corresponding I/V curves constructed. 100 uM of zoxazolamine activated the K(Ca) current.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:04 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:04 GMT 2025`
Record UNII	9DOW362Q29
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZOXAZOLAMINE

Official Name

English

CONTRAZOLE

Preferred Name

English

URI-BOI

Brand Name

English

NSC-24995

Code

English

FLEXIN

Brand Name

English

ZOXAZOLAMINE [MI]

Common Name

English

MIAZOL

Brand Name

English

5-CHLORO-2-BENZOXAZOLAMINE

Systematic Name

English

ZOXAMINE

Brand Name

English

ZOXINE

Brand Name

English

MCN-485

Code

English

zoxazolamine [INN]

Common Name

English

2-AMINO-5-CHLOROBENZOXAZOLE

Systematic Name

English

DEFLEXOL

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C921